Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

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DOI

  • Carlota Castro-Espin, Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain.
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  • Antonio Agudo, Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain.
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  • Catalina Bonet, Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain.
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  • Verena Katzke, German Cancer Research Center (DKFZ)
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  • Renée Turzanski-Fortner, German Cancer Research Center (DKFZ)
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  • Krasimira Aleksandrova, Unit for Nutrition Research, Faculty of Food Science and Nutrition
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  • Matthias B Schulze, Univ Potsdam, University of Potsdam, Potsdam Res Inst Multilingualism
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  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
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  • Christina C Dahm
  • José-Ramón Quirós, Public Health and Health Planning Directorate
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  • María-José Sánchez, Escuela Andaluza de Salud Pública (EASP), Granada
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  • Pilar Amiano, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
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  • María-Dolores Chirlaque, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
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  • Eva Ardanaz, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
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  • Giovanna Masala, Institute for Cancer Research
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  • Sabina Sieri, Epidemiology and Prevention Unit, Milan, Italy.
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  • Rosario Tumino, Cancer Registry and Histopathology Department, 'Civic - M.P.Arezzo' Hospital, Italy.
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  • Carlotta Sacerdote, Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Via Santena 7, 10126, Turin, Italy.
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  • Salvatore Panico, Federico II University Hospital
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  • Anne M May, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr
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  • Stina Bodén, University of Umeå, Umeå, Sweden.
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  • Inger T Gram, University of Tromsø, Tromsø
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  • Guri Skeie, University of Tromsø, Tromsø
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  • Nasser Laouali, University Paris-Saclay, University Paris-Sud, Villejuif
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  • Sanam Shah, University Paris-Saclay, University Paris-Sud, Villejuif
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  • Gianluca Severi, University Paris-Saclay, University Paris-Sud, Villejuif
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  • Dagfinn Aune, Imperial Coll London, Imperial College London, UKDRI
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  • Melissa A Merritt, Imperial Coll London, Imperial College London, UKDRI
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  • Manon Cairat, Biomarker Group, Nutrition and Metabolism Section, IARC, Lyon
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  • Elisabete Weiderpass, Office of the Director, International Agency For Research On Cancer.
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  • Elio Riboli, Imperial Coll London, Imperial College London, UKDRI
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  • Laure Dossus, Biomarker Group, Nutrition and Metabolism Section, IARC, Lyon
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  • Paula Jakszyn, Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain.

The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01-1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04-1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01-1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
ISSN0393-2990
DOI
StatusE-pub ahead of print - 20 jun. 2021

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