Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

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  • Marta Solans, Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology, Girona, Spain., University of Girona, CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Yolanda Benavente, Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology (ICO-IDIBELL), Av. Gran Via de l'Hospitalet 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Marc Saez, Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Antonio Agudo, Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain., Spanien
  • Paula Jakszyn, Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain., Spanien
  • Sabine Naudin, Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150, Cours Albert Thomas, 69372, Lyon Cedex 08, France. freislingh@iarc.fr., Frankrig
  • Fatemeh Saberi Hosnijeh, Utrecht University, Erasmus University Medical Center, Holland
  • Marc Gunter, Nutritional Epidemiology Group (NEP), International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Inge Huybrechts, Nutritional Epidemiology Group (NEP), International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Pietro Ferrari, International Agency for Research on Cancer, Frankrig
  • Caroline Besson, Institut Gustave Roussy, Villejuif, France., Université Paris-Saclay, Frankrig
  • Yahya Mahamat-Saleh, Institut Gustave Roussy, Villejuif, France., Université Paris-Saclay, Frankrig
  • Marie-Christine Boutron-Ruault, Institut Gustave Roussy, Villejuif, France., Université Paris-Saclay, Frankrig
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Tyskland
  • Rudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Tyskland
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany., Tyskland
  • Cristina Lasheras, Department of Functional Biology, Faculty of Medicine, University of Oviedo, CP 33006 Oviedo, Asturias, Spain., Spanien
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • María Dolores Chirlaque, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Eva Ardanaz, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Navarra Public Health Institute, c/Leyre 15, Pamplona 31003, Pamplona, Spain., CIBER Epidemiology and Public Health CIBERESP, Spanien
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Paolo Vineis, Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Elio Riboli, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, National and Kapodistrian University of Athens, Hellenic Health Foundation, Athens, Grækenland
  • Elisavet Valanou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Giovanna Masala, Cancer Risk Factors and Life-Style Epidemiology Unit. Institute for Cancer Research, Prevention and Clinical Network - ISPRO, 50141, Florence, Italy., Italien
  • Claudia Agnoli, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, "Civic M.P. Arezzo" Hospital, ASP, Ragusa, Italy., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Amalia Mattiello, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy., Italien
  • Guri Skeie, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway., Norge
  • Elisabete Weiderpass, University of Tromsø, Cancer Registry of Norway Institute of Population-Based Cancer Research, Karolinska Institutet, Helsinki University, Finland
  • Mats Jerkeman, Department of Oncology, Skåne University Hospital, Lund, Sweden;, Sverige
  • Joana Alves Dias, Lund University, Sverige
  • Florentin Späth, Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Sverige
  • Lena Maria Nilsson, Department of Public Health and Clinical Medicine, Nutritional research and Arcum-Arctic Research Centre, Umeå University, Umeå, Sweden., Sverige
  • Christina C Dahm
  • Kim Overvad
  • Kristina Elin Nielsen Petersen, Danish Cancer Society Research Center, Danmark
  • Anne Tjønneland, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Danish Cancer Society Research Center, Danmark
  • Silvia de Sanjose, PATH, Reproductive Health, Seattle, USA., CIBER Epidemiology and Public Health CIBERESP, Catalan Institute of Oncology, Barcelona, USA
  • Roel Vermeulen, Utrecht University, Holland
  • Alexandra Nieters, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Tyskland
  • Delphine Casabonne, Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology (ICO-IDIBELL), Av. Gran Via de l'Hospitalet 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain. dcasabonne@iconcologia.net., CIBER Epidemiology and Public Health CIBERESP, Spanien

INTRODUCTION: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study.

METHODS: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders.

RESULTS: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13).

CONCLUSIONS: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Nutrition
Vol/bind59
Sider (fra-til)813-823
Antal sider11
ISSN1436-6207
DOI
StatusUdgivet - mar. 2020

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