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Abstract
The large amount and high quality of genomic data available today enables, in principle, accurate inference of evolutionary histories of observed populations. The WrightFisher model is one of the most widely used models for this purpose. It describes the stochastic behavior in time of allele frequencies and the influence of evolutionary pressures, such as mutation and selection. Despite its simple mathematical formulation, exact results for the distribution of allele frequency (DAF) as a function of time are not available in closed analytic form. Existing approximations build on the computationally intensive diffusion limit, or rely on matching moments of the DAF. One of the momentbased approximations relies on the beta distribution, which can accurately describe the DAF when the allele frequency is not close to the boundaries (zero and one). Nonetheless, under a WrightFisher model, the probability of being on the boundary can be positive, corresponding to the allele being either lost or fixed. Here, we introduce the beta with spikes, an extension of the beta approximation, which explicitly models the loss and fixation probabilities as two spikes at the boundaries. We show that the addition of spikes greatly improves the quality of the approximation. We additionally illustrate, using both simulated and real data, how the beta with spikes can be used for inference of divergence times between populations, with comparable performance to an existing stateoftheart method.
Originalsprog  Engelsk 

Tidsskrift  Genetics 
Vol/bind  201 
Nummer  3 
Sider (fratil)  11331141 
ISSN  00166731 
Status  Udgivet  nov. 2015 
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