Induction of humoral and cellular immune responses against the HIV-1 envelope protein using γ-retroviral virus-like particles

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ABSTRACT: This study evaluates the immunogenicity of the HIV envelope protein (env) in mice presented either attached to γ-retroviral virus-like-particles (VLPs), associated with cell-derived microsomes or as solubilized recombinant protein (gp160). The magnitude and polyfunctionality of the cellular immune response was enhanced when delivering HIV env in the VLP or microsome form compared to recombinant gp160. Humoral responses measured by antibody titres were comparable across the groups and low levels of antibody neutralization were observed. Lastly, we identified stronger IgG2a class switching in the two particle-delivered antigen vaccinations modalities compared to recombinant gp160.
OriginalsprogEngelsk
TidsskriftVirology Journal
Vol/bind8
Sider (fra-til)381
ISSN1743-422X
DOI
StatusUdgivet - 1 jan. 2011

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