Induced mutations in circadian clock regulator Mat-a facilitated short-season adaptation and range extension in cultivated barley

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  • Shakhira Zakhrabekova, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Ukendt
  • Simon P Gough, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • Ilka Braumann, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • André H Müller, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • Joakim Lundqvist, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • Katharina Ahmann, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • Christoph Dockter, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark
  • Izabela Matyszczak, Danmark
  • Marzena Kurowska, Department of Genetics, Faculty of Biology and Environmental Protection, University of Silesia, Polen
  • Arnis Druka, James Hutton Institute, Invergowrie, Dundee DD2 5DA, Storbritannien
  • Robbie Waugh, James Hutton Institute, Invergowrie, Dundee DD2 5DA, Storbritannien
  • Andreas Graner, Leibniz Institute of Plant Genetics and Crop Plant Research, Tyskland
  • Nils Stein, Leibniz Institute of Plant Genetics and Crop Plant Research, Tyskland
  • Burkhard Steuernagel, Leibniz Institute of Plant Genetics and Crop Plant Research, Tyskland
  • Udda Lundqvist, Nordic Genetic Resource Center, Sverige
  • Mats Hansson, Carlsberg Laboratory, 1799 Copenhagen V, Denmark., Danmark

Time to flowering has an important impact on yield and has been a key trait in the domestication of crop plants and the spread of agriculture. In 1961, the cultivar Mari (mat-a.8) was the very first induced early barley (Hordeum vulgare L.) mutant to be released into commercial production. Mari extended the range of two-row spring barley cultivation as a result of its photoperiod insensitivity. Since its release, Mari or its derivatives have been used extensively across the world to facilitate short-season adaptation and further geographic range extension. By exploiting an extended historical collection of early-flowering mutants of barley, we identified Praematurum-a (Mat-a), the gene responsible for this key adaptive phenotype, as a homolog of the Arabidopsis thaliana circadian clock regulator Early Flowering 3 (Elf3). We characterized 87 induced mat-a mutant lines and identified >20 different mat-a alleles that had clear mutations leading to a defective putative ELF3 protein. Expression analysis of HvElf3 and Gigantea in mutant and wild-type plants demonstrated that mat-a mutations disturb the flowering pathway, leading to the early phenotype. Alleles of Mat-a therefore have important and demonstrated breeding value in barley but probably also in many other day-length-sensitive crop plants, where they may tune adaptation to different geographic regions and climatic conditions, a critical issue in times of global warming.

OriginalsprogEngelsk
TidsskriftPNAS (Proceedings of the National Academy of Sciences of the United States of America)
Vol/bind109
Nummer11
Sider (fra-til)4326-4331
Antal sider6
ISSN0027-8424
DOI
StatusUdgivet - 13 mar. 2012

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