Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF

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Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus to
sortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depression
and 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for association
with depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaire
and participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potential
determinants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophic
factor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increase
of serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation between
serum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated with
depression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake and
body mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in our
final multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to altered
activity of neurotrophic factors.
TidsskriftTranslational Psychiatry
StatusUdgivet - 2015

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