Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF

Henriette Nørmølle Buttenschøn; Ditte Demontis; Mathias Kaas Ollendorff; Betina Elfving; Simon Mølgaard Jensen; Camilla Gustafsen; L. Kærlev; Claus Munck Petersen; Anders Børglum; Ole Mors; Simon Glerup Pedersen

doi:10.1038/tp.2015.167

Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF

Henriette Nørmølle Buttenschøn, Ditte Demontis, Mathias Kaas Ollendorff, Betina Elfving, Simon Mølgaard Jensen, Camilla Gustafsen, L. Kærlev, Claus Munck Petersen, Anders Børglum, Ole Mors, Simon Glerup Pedersen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

44 Citationer (Scopus)

Abstract

Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus to
sortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depression
and 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for association
with depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaire
and participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potential
determinants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophic
factor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increase
of serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation between
serum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated with
depression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake and
body mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in our
final multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to altered
activity of neurotrophic factors.

Originalsprog	Engelsk
Tidsskrift	Translational Psychiatry
Vol/bind	5
Nummer	e677
ISSN	2158-3188
DOI	https://doi.org/10.1038/tp.2015.167
Status	Udgivet - 2015

Adgang til dokumentet

10.1038/tp.2015.167

Citationsformater

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title = "Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF",

abstract = "Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus tosortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depressionand 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for associationwith depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaireand participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potentialdeterminants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophicfactor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increaseof serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation betweenserum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated withdepression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake andbody mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in ourfinal multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to alteredactivity of neurotrophic factors.",

author = "Buttensch{\o}n, {Henriette N{\o}rm{\o}lle} and Ditte Demontis and Ollendorff, {Mathias Kaas} and Betina Elfving and Jensen, {Simon M{\o}lgaard} and Camilla Gustafsen and L. K{\ae}rlev and Petersen, {Claus Munck} and Anders B{\o}rglum and Ole Mors and Pedersen, {Simon Glerup}",

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Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF. / Buttenschøn, Henriette Nørmølle ; Demontis, Ditte ; Ollendorff, Mathias Kaas et al.
I: Translational Psychiatry, Bind 5, Nr. e677, 2015.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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T1 - Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF

AU - Buttenschøn, Henriette Nørmølle

AU - Demontis, Ditte

AU - Ollendorff, Mathias Kaas

AU - Elfving, Betina

AU - Jensen, Simon Mølgaard

AU - Gustafsen, Camilla

AU - Kærlev, L.

AU - Petersen, Claus Munck

AU - Børglum, Anders

AU - Mors, Ole

AU - Pedersen, Simon Glerup

PY - 2015

Y1 - 2015

N2 - Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus tosortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depressionand 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for associationwith depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaireand participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potentialdeterminants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophicfactor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increaseof serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation betweenserum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated withdepression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake andbody mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in ourfinal multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to alteredactivity of neurotrophic factors.

AB - Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus tosortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depressionand 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for associationwith depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaireand participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potentialdeterminants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophicfactor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increaseof serum sortilin levels in depressed individuals compared with controls (P = 0.0002) and significant positive correlation betweenserum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated withdepression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake andbody mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in ourfinal multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to alteredactivity of neurotrophic factors.

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DO - 10.1038/tp.2015.167

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SN - 2158-3188

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JO - Translational Psychiatry

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