Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Sofie Vestergaard Fonager; Gudrun Winther; Thomas Rea Wittenborn; Lisbeth Jensen; Cecilia Fahlquist-Hagert; Lisbeth Ahm Hansen; Ernst-Martin Füchtbauer; Marina Romero-Ramos; Søren Egedal Degn

doi:10.1016/j.jneuroim.2022.577927

Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Sofie Vestergaard Fonager, Gudrun Winther, Thomas Rea Wittenborn, Lisbeth Jensen, Cecilia Fahlquist-Hagert, Lisbeth Ahm Hansen, Ernst-Martin Füchtbauer, Marina Romero-Ramos, Søren Egedal Degn^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. Microglial morphology in offspring CNS was assessed using immunohistochemistry. In contrast to prior findings, our results indicate that BXSB/MpJ mothers display a mild autoimmune phenotype, which does not significantly impact the offspring.

Originalsprog	Engelsk
Artikelnummer	577927
Tidsskrift	Journal of Neuroimmunology
Vol/bind	370
Antal sider	12
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2022.577927
Status	Udgivet - 15 sep. 2022

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10.1016/j.jneuroim.2022.577927Licens: CC BY

Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspringForlagets udgivne version, 2,86 MBLicens: CC BY

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Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M., & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Artikel 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

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title = "Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring",

abstract = "Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. Microglial morphology in offspring CNS was assessed using immunohistochemistry. In contrast to prior findings, our results indicate that BXSB/MpJ mothers display a mild autoimmune phenotype, which does not significantly impact the offspring.",

keywords = "Animals, Antibodies, Antinuclear, Autoantibodies, Disease Models, Animal, Immunoglobulin G, Lupus Erythematosus, Systemic/genetics, Mice",

author = "Fonager, {Sofie Vestergaard} and Gudrun Winther and Wittenborn, {Thomas Rea} and Lisbeth Jensen and Cecilia Fahlquist-Hagert and Hansen, {Lisbeth Ahm} and Ernst-Martin F{\"u}chtbauer and Marina Romero-Ramos and Degn, {S{\o}ren Egedal}",

year = "2022",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2022.577927",

language = "English",

volume = "370",

journal = "Journal of Neuroimmunology",

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Fonager, SV , Winther, G , Wittenborn, TR , Jensen, L, Fahlquist-Hagert, C, Hansen, LA , Füchtbauer, E-M , Romero-Ramos, M & Degn, SE 2022, 'Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring', Journal of Neuroimmunology, bind 370, 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. / Fonager, Sofie Vestergaard ; Winther, Gudrun ; Wittenborn, Thomas Rea et al.
I: Journal of Neuroimmunology, Bind 370, 577927, 15.09.2022.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

AU - Fonager, Sofie Vestergaard

AU - Winther, Gudrun

AU - Wittenborn, Thomas Rea

AU - Jensen, Lisbeth

AU - Fahlquist-Hagert, Cecilia

AU - Hansen, Lisbeth Ahm

AU - Füchtbauer, Ernst-Martin

AU - Romero-Ramos, Marina

AU - Degn, Søren Egedal

PY - 2022/9/15

Y1 - 2022/9/15

N2 - Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. Microglial morphology in offspring CNS was assessed using immunohistochemistry. In contrast to prior findings, our results indicate that BXSB/MpJ mothers display a mild autoimmune phenotype, which does not significantly impact the offspring.

AB - Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. Microglial morphology in offspring CNS was assessed using immunohistochemistry. In contrast to prior findings, our results indicate that BXSB/MpJ mothers display a mild autoimmune phenotype, which does not significantly impact the offspring.

KW - Animals

KW - Antibodies, Antinuclear

KW - Autoantibodies

KW - Disease Models, Animal

KW - Immunoglobulin G

KW - Lupus Erythematosus, Systemic/genetics

KW - Mice

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U2 - 10.1016/j.jneuroim.2022.577927

DO - 10.1016/j.jneuroim.2022.577927

M3 - Journal article

C2 - 35858501

SN - 0165-5728

VL - 370

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577927

ER -

Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Abstract

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