Aarhus University Seal / Aarhus Universitets segl

Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children : prospective population-based study. / Basu, Archana; Farkas, Dóra Körmendiné; Jiang, Tammy; Koenen, Karestan C.; Lash, Timothy L.; Sørensen, Henrik Toft; Gradus, Jaimie L.

I: British Journal of Psychiatry, Bind 217, Nr. 1, 07.2020, s. 377-382.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{d0db13322fc94907846cdcbff67d06f8,
title = "Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study",
abstract = "BACKGROUND: Prospective population-based studies of psychiatric comorbidity following trauma and severe stress exposure in children are limited. AIMS: To examine incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children using Danish national healthcare system registries. METHOD: Children (6-15 years of age) with a severe stress or adjustment disorder (ICD-10) between 1995 and 2011 (n = 11 292) were followed prospectively for an average of 5.8 years. Incident depressive, anxiety and behavioural disorder diagnoses were examined relative to an age- and gender-matched comparison cohort (n = 56 460) using Cox proportional hazards regression models. Effect modification by gender was examined through stratified analyses. RESULTS: All severe stress and adjustment disorder diagnoses were associated with increased rates for all incident outcome disorders relative to the comparison cohort. For instance, adjustment disorders were associated with higher rates of incident depressive (rate ratio RR = 6.8; 95% CI 6.0-7.7), anxiety (RR = 5.3; 95% CI 4.5-6.4), and behavioural disorders (RR = 7.9; 95% CI 6.6-9.3). Similarly, PTSD was also associated with higher rates of depressive (RR = 7.4; 95% CI 4.2-13), anxiety (RR = 7.1; 95% CI 3.5-14) and behavioural disorder (RR = 4.9; 95% CI 2.3-11) diagnoses. There was no evidence of gender-related differences. CONCLUSIONS: Stress disorders varying in symptom constellation and severity are associated with a range of incident psychiatric disorders in children. Transdiagnostic assessments within a longitudinal framework are needed to characterise the course of post-trauma or severe stressor psychopathology.",
keywords = "adjustment disorders, childhood experience, epidemiology, post-traumatic stress disorder, Trauma",
author = "Archana Basu and Farkas, {D{\'o}ra K{\"o}rmendin{\'e}} and Tammy Jiang and Koenen, {Karestan C.} and Lash, {Timothy L.} and S{\o}rensen, {Henrik Toft} and Gradus, {Jaimie L.}",
year = "2020",
month = jul,
doi = "10.1192/bjp.2019.247",
language = "English",
volume = "217",
pages = "377--382",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "ROYAL COLL PSYCHIATRISTS",
number = "1",

}

RIS

TY - JOUR

T1 - Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children

T2 - prospective population-based study

AU - Basu, Archana

AU - Farkas, Dóra Körmendiné

AU - Jiang, Tammy

AU - Koenen, Karestan C.

AU - Lash, Timothy L.

AU - Sørensen, Henrik Toft

AU - Gradus, Jaimie L.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: Prospective population-based studies of psychiatric comorbidity following trauma and severe stress exposure in children are limited. AIMS: To examine incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children using Danish national healthcare system registries. METHOD: Children (6-15 years of age) with a severe stress or adjustment disorder (ICD-10) between 1995 and 2011 (n = 11 292) were followed prospectively for an average of 5.8 years. Incident depressive, anxiety and behavioural disorder diagnoses were examined relative to an age- and gender-matched comparison cohort (n = 56 460) using Cox proportional hazards regression models. Effect modification by gender was examined through stratified analyses. RESULTS: All severe stress and adjustment disorder diagnoses were associated with increased rates for all incident outcome disorders relative to the comparison cohort. For instance, adjustment disorders were associated with higher rates of incident depressive (rate ratio RR = 6.8; 95% CI 6.0-7.7), anxiety (RR = 5.3; 95% CI 4.5-6.4), and behavioural disorders (RR = 7.9; 95% CI 6.6-9.3). Similarly, PTSD was also associated with higher rates of depressive (RR = 7.4; 95% CI 4.2-13), anxiety (RR = 7.1; 95% CI 3.5-14) and behavioural disorder (RR = 4.9; 95% CI 2.3-11) diagnoses. There was no evidence of gender-related differences. CONCLUSIONS: Stress disorders varying in symptom constellation and severity are associated with a range of incident psychiatric disorders in children. Transdiagnostic assessments within a longitudinal framework are needed to characterise the course of post-trauma or severe stressor psychopathology.

AB - BACKGROUND: Prospective population-based studies of psychiatric comorbidity following trauma and severe stress exposure in children are limited. AIMS: To examine incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children using Danish national healthcare system registries. METHOD: Children (6-15 years of age) with a severe stress or adjustment disorder (ICD-10) between 1995 and 2011 (n = 11 292) were followed prospectively for an average of 5.8 years. Incident depressive, anxiety and behavioural disorder diagnoses were examined relative to an age- and gender-matched comparison cohort (n = 56 460) using Cox proportional hazards regression models. Effect modification by gender was examined through stratified analyses. RESULTS: All severe stress and adjustment disorder diagnoses were associated with increased rates for all incident outcome disorders relative to the comparison cohort. For instance, adjustment disorders were associated with higher rates of incident depressive (rate ratio RR = 6.8; 95% CI 6.0-7.7), anxiety (RR = 5.3; 95% CI 4.5-6.4), and behavioural disorders (RR = 7.9; 95% CI 6.6-9.3). Similarly, PTSD was also associated with higher rates of depressive (RR = 7.4; 95% CI 4.2-13), anxiety (RR = 7.1; 95% CI 3.5-14) and behavioural disorder (RR = 4.9; 95% CI 2.3-11) diagnoses. There was no evidence of gender-related differences. CONCLUSIONS: Stress disorders varying in symptom constellation and severity are associated with a range of incident psychiatric disorders in children. Transdiagnostic assessments within a longitudinal framework are needed to characterise the course of post-trauma or severe stressor psychopathology.

KW - adjustment disorders

KW - childhood experience

KW - epidemiology

KW - post-traumatic stress disorder

KW - Trauma

UR - http://www.scopus.com/inward/record.url?scp=85087320568&partnerID=8YFLogxK

U2 - 10.1192/bjp.2019.247

DO - 10.1192/bjp.2019.247

M3 - Journal article

C2 - 31755399

AN - SCOPUS:85087320568

VL - 217

SP - 377

EP - 382

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 1

ER -