Incident Chronic Rhinosinusitis Is Associated With Impaired Sleep Quality: Results of the RHINE Study

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  • Caroline Bengtsson, Department of Surgical Sciences, Otorhinolaryngology, Head and Neck Surgery, Uppsala University, Uppsala, Sweden., Sverige
  • Lars Jonsson, Department of Surgical Sciences, Otorhinolaryngology, Head and Neck Surgery, Uppsala University, Uppsala, Sweden., Sverige
  • Mats Holmström, Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska University Hospital, Huddinge, Sweden., Sverige
  • Johan Hellgren, University of Gothenburg, Sverige
  • Karl Franklin, Department of Surgical and perioperative Sciences/Surgery, Umeå University, Umeå, Sweden., Sverige
  • Tórarinn Gíslason, Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland ; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Island
  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sverige
  • Ane Johannessen, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Institute of Clinical Medicine, University of Bergen, Bergen, Norway., Norge
  • Rain Jõgi, Department of Pulmonology, Tartu University Hospital, Tartu, Estonia., Estland
  • Vivi Schlünssen
  • Christer Janson, Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden., Sverige
  • Eva Lindberg, Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden., Sverige

STUDY OBJECTIVES: Chronic rhinosinusitis (CRS) is a common inflammatory disease of the nasal cavity and paranasal sinuses. Associations between CRS and poor sleep quality have been reported. This 10-year follow-up study investigates possible associations between incident CRS and sleep quality.

METHODS: A questionnaire was sent to 16,500 individuals in Sweden, Norway, Denmark, Iceland and Estonia in 2000. It included questions on airway diseases, age, sex, body mass index, smoking habits, comorbidities, education and sleep quality. In 2010, a second questionnaire was sent to the same individuals, with a response rate of 53%. A subgroup of 5,145 individuals without nasal symptoms in 2000 was studied. Multiple logistic regression was performed to examine associations between CRS (defined according to the European position paper on rhinosinusitis and nasal polyps epidemiological criteria) at follow-up and sleep quality, with adjustment for potential confounders. Individuals with the respective sleep problem at baseline were excluded.

RESULTS: Over 10 years, 141 (2.7%) of the individuals without nasal symptoms in 2000 had developed CRS. CRS was associated with difficulties inducing sleep (adjusted odds ratio 2.81 [95% CI 1.67-4.70]), difficulties maintaining sleep (2.07 [1.35-3.18]), early morning awakening (3.03 [1.91-4.81]), insomnia (2.21 [1.46-3.35]), excessive daytime sleepiness (2.85 [1.79-4.55]), and snoring (3.31 [2.07-5.31]). Three insomnia symptoms at baseline increased the risk of CRS at follow-up by 5.00 (1.93-12.99).

CONCLUSIONS: Incident CRS is associated with impaired sleep quality and excessive daytime sleepiness. Insomnia symptoms may be a risk factor for the development of CRS.

OriginalsprogEngelsk
TidsskriftThe Journal of Clinical Sleep Medicine
Vol/bind15
Nummer6
Sider (fra-til)899-905
Antal sider7
ISSN1550-9389
DOI
StatusUdgivet - 15 jun. 2019

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© 2019 American Academy of Sleep Medicine.

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