Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy

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Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy. / Bek, Toke.

I: Current Eye Research, Bind 45, Nr. 8, 2020, s. 986-991.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{8c64e6ab2ec342b791e28cc21eb34d7d,
title = "Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy",
abstract = "Purpose: Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. Materials and methods: Survival data was used to analyze prospectively collected epidemiological and clinical data to describe the incidence and risk factors for the occurrence of PDR in all 1,235 patients photocoagulation treated for DM in a defined population from the Aarhus area, Denmark, from January 1. 1993 until December 31. 2016. Results: Among 1,204 (97.5%) of the patients in whom the subsequent clinical history was known, 536 (44.5%) had died and 131 (10.9%) had received panretinal photocoagulation for PDR. The cumulative incidence of developing PDR after photocoagulation for diabetic maculopathy increased with time to reach a plateau around 13% after approximately 15 years. Earlier age at diagnosis of diabetes and higher HbA1c at the time of macular treatment were significant risk factors for the development of PDR, whereas gender, diabetes type, body mass index, known diabetes duration at the time of macular photocoagulation and blood pressure were not significant risk factors. Conclusions: In patients treated with retinal photocoagulation for DM, a tight metabolic control is accompanied with a reduced risk for subsequent progression to PDR. In the treated patients who do not develop PDR, the control interval can be gradually increased with time.",
keywords = "Diabetic maculopathy, population study, proliferative diabetic retinopathy, retinal photocoagulation, survival analysis, MELLITUS, PREVALENCE, BLOOD-PRESSURE, ARHUS COUNTY, PATHOPHYSIOLOGY, LASER TREATMENT, OXYGEN-SATURATION, TYPE-2, EPIDEMIOLOGY, PROGRESSION",
author = "Toke Bek",
year = "2020",
doi = "10.1080/02713683.2020.1712729",
language = "English",
volume = "45",
pages = "986--991",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Taylor & Francis ",
number = "8",

}

RIS

TY - JOUR

T1 - Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy

AU - Bek, Toke

PY - 2020

Y1 - 2020

N2 - Purpose: Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. Materials and methods: Survival data was used to analyze prospectively collected epidemiological and clinical data to describe the incidence and risk factors for the occurrence of PDR in all 1,235 patients photocoagulation treated for DM in a defined population from the Aarhus area, Denmark, from January 1. 1993 until December 31. 2016. Results: Among 1,204 (97.5%) of the patients in whom the subsequent clinical history was known, 536 (44.5%) had died and 131 (10.9%) had received panretinal photocoagulation for PDR. The cumulative incidence of developing PDR after photocoagulation for diabetic maculopathy increased with time to reach a plateau around 13% after approximately 15 years. Earlier age at diagnosis of diabetes and higher HbA1c at the time of macular treatment were significant risk factors for the development of PDR, whereas gender, diabetes type, body mass index, known diabetes duration at the time of macular photocoagulation and blood pressure were not significant risk factors. Conclusions: In patients treated with retinal photocoagulation for DM, a tight metabolic control is accompanied with a reduced risk for subsequent progression to PDR. In the treated patients who do not develop PDR, the control interval can be gradually increased with time.

AB - Purpose: Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. Materials and methods: Survival data was used to analyze prospectively collected epidemiological and clinical data to describe the incidence and risk factors for the occurrence of PDR in all 1,235 patients photocoagulation treated for DM in a defined population from the Aarhus area, Denmark, from January 1. 1993 until December 31. 2016. Results: Among 1,204 (97.5%) of the patients in whom the subsequent clinical history was known, 536 (44.5%) had died and 131 (10.9%) had received panretinal photocoagulation for PDR. The cumulative incidence of developing PDR after photocoagulation for diabetic maculopathy increased with time to reach a plateau around 13% after approximately 15 years. Earlier age at diagnosis of diabetes and higher HbA1c at the time of macular treatment were significant risk factors for the development of PDR, whereas gender, diabetes type, body mass index, known diabetes duration at the time of macular photocoagulation and blood pressure were not significant risk factors. Conclusions: In patients treated with retinal photocoagulation for DM, a tight metabolic control is accompanied with a reduced risk for subsequent progression to PDR. In the treated patients who do not develop PDR, the control interval can be gradually increased with time.

KW - Diabetic maculopathy

KW - population study

KW - proliferative diabetic retinopathy

KW - retinal photocoagulation

KW - survival analysis

KW - MELLITUS

KW - PREVALENCE

KW - BLOOD-PRESSURE

KW - ARHUS COUNTY

KW - PATHOPHYSIOLOGY

KW - LASER TREATMENT

KW - OXYGEN-SATURATION

KW - TYPE-2

KW - EPIDEMIOLOGY

KW - PROGRESSION

UR - http://www.scopus.com/inward/record.url?scp=85078590059&partnerID=8YFLogxK

U2 - 10.1080/02713683.2020.1712729

DO - 10.1080/02713683.2020.1712729

M3 - Journal article

C2 - 31920110

AN - SCOPUS:85078590059

VL - 45

SP - 986

EP - 991

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 8

ER -