In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

TY - JOUR

T1 - In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

AU - Hansen, Allan K

AU - Damholdt, Malene Flensborg

AU - Fedorova, Tatyana D

AU - Knudsen, Karoline

AU - Parbo, Peter

AU - Ismail, Rola

AU - Østergaard, Karen

AU - Brooks, David J

AU - Borghammer, Per

N1 - © 2017 International Parkinson and Movement Disorder Society.

PY - 2017/6

Y1 - 2017/6

N2 - Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. Objectives: To describe tau aggregation in PD patients. Methods: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment. Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Conclusion: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage.

AB - Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. Objectives: To describe tau aggregation in PD patients. Methods: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment. Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Conclusion: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85020299554&partnerID=8YFLogxK

U2 - 10.1002/mds.26961

DO - 10.1002/mds.26961

M3 - Journal article

C2 - 28256006

SN - 0885-3185

VL - 32

SP - 922

EP - 927

JO - Movement Disorders

JF - Movement Disorders

IS - 6

ER -