Aarhus University Seal / Aarhus Universitets segl

In the Search of Marine Pestiviruses: First Case of Phocoena Pestivirus in a Belt Sea Harbour Porpoise

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Iben Stokholm, Københavns Universitet, University of Veterinary Medicine Hannover, Foundation
  • ,
  • Nicole Fischer, University of Hamburg
  • ,
  • Christine Baechlein, University of Veterinary Medicine Hannover, Foundation
  • ,
  • Alexander Postel, University of Veterinary Medicine Hannover, Foundation
  • ,
  • Anders Galatius
  • Line Anker Kyhn
  • Charlotte Bie Thøstesen, Fisheries and Maritime Museum
  • ,
  • Sara Persson, Swedish Museum of Natural History
  • ,
  • Ursula Siebert
  • Morten Tange Olsen, Københavns Universitet
  • ,
  • Paul Becher, University of Veterinary Medicine Hannover, Foundation

Pestiviruses are widespread pathogens causing severe acute and chronic diseases among terrestrial mammals. Recently, Phocoena pestivirus (PhoPeV) was described in harbour porpoises (Phocoena phocoena) of the North Sea, expanding the host range to marine mammals. While the role of the virus is unknown, intrauterine infections with the most closely related pestiviruses— Bungowannah pestivirus (BuPV) and Linda virus (LindaV)—can cause increased rates of abortions and deaths in young piglets. Such diseases could severely impact already vulnerable harbour porpoise populations. Here, we investigated the presence of PhoPeV in 77 harbour porpoises, 277 harbour seals (Phoca vitulina), grey seals (Halichoerus grypus) and ringed seals (Pusa hispida) collected in the Baltic Sea region between 2002 and 2019. The full genome sequence of a pestivirus was obtained from a juvenile female porpoise collected along the coast of Zealand in Denmark in 2011. The comparative Bayesian phylogenetic analyses revealed a close relationship between the new PhoPeV sequence and previously published North Sea sequences with a recent divergence from genotype 1 sequences between 2005 and 2009. Our findings provide further insight into the circulation of PhoPeV and expand the distribution from the North Sea to the Baltic Sea region with possible implications for the vulnerable Belt Sea and endangered Baltic Proper harbour porpoise populations.

OriginalsprogEngelsk
Artikelnummer161
TidsskriftViruses
Vol/bind14
Nummer1
Antal sider11
ISSN1999-4915
DOI
StatusUdgivet - jan. 2022

Bibliografisk note

Funding Information:
This work was supported by matching funding from the University of Copenhagen, Denmark to I.S. and M.T.O., the University of Veterinary Medicine Hannover to I.S. and the ?BONUS BALTHEALTH? project awarded to U.S. and M.T.O. BONUS BALTHEALTH received funding from BONUS (Art. 185). BONUS BALTHEALTH was funded jointly by the E.U., Innovation Fund Denmark (grants 6180-00001B and 6180-00002B), Forschungszentrum J?lich GmbH, German Federal Ministry of Education and Research (grant FKZ 03F0767A), Academy of Finland (grant 311966) and Swedish Foundation for Strategic Environmental Research (MISTRA).

Funding Information:
Funding: This work was supported by matching funding from the University of Copenhagen, Denmark to I.S. and M.T.O., the University of Veterinary Medicine Hannover to I.S. and the “BONUS BALTHEALTH” project awarded to U.S. and M.T.O. BONUS BALTHEALTH received funding from BONUS (Art. 185). BONUS BALTHEALTH was funded jointly by the E.U., Innovation Fund Denmark (grants 6180-00001B and 6180-00002B), Forschungszentrum Jülich GmbH, German Federal Ministry of Education and Research (grant FKZ 03F0767A), Academy of Finland (grant 311966) and Swedish Foundation for Strategic Environmental Research (MISTRA).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Se relationer på Aarhus Universitet Citationsformater

ID: 257252414