In Situ lactate dehydrogenase activiy-a novel renal cortical imaging biomarker of tubular injury?

TY - CONF

T1 - In Situ lactate dehydrogenase activiy-a novel renal cortical imaging biomarker of tubular injury?

AU - Nielsen, Per Mose

AU - Laustsen, Christoffer

AU - Bertelsen, Lotte Bonde

AU - Qi, Haiyun

AU - Mikkelsen, Emmeli

AU - Kristensen, Marie-Louise vinvad

AU - Nørregaard, Rikke

AU - Stødkilde-Jørgensen, Hans

PY - 2016/4/3

Y1 - 2016/4/3

N2 - Renal ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI) in several disease states, including hypovolemic shock, sepsis, surgery. Imbalance in energy metabolism and mitochondrial function is a hallmark in IRI which can be caused by mechanisms like oxidative stress, apoptosis and inflammation. Lactate dehydrogenase (LDH) activity has previously been suggested as a renal tubular injury marker, but has a major limitation in the sense that it can only be measured in terminal kidneys. By the use of a hyperpolarized [1-13C]pyruvate magnetic resonance imaging (MRI) approach to monitor metabolic changes, we here investigate LDH activity and renal metabolism after IRI. This procedure gives a novel non-invasive method for investigation renal tissue injury in concern with IRI.

AB - Renal ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI) in several disease states, including hypovolemic shock, sepsis, surgery. Imbalance in energy metabolism and mitochondrial function is a hallmark in IRI which can be caused by mechanisms like oxidative stress, apoptosis and inflammation. Lactate dehydrogenase (LDH) activity has previously been suggested as a renal tubular injury marker, but has a major limitation in the sense that it can only be measured in terminal kidneys. By the use of a hyperpolarized [1-13C]pyruvate magnetic resonance imaging (MRI) approach to monitor metabolic changes, we here investigate LDH activity and renal metabolism after IRI. This procedure gives a novel non-invasive method for investigation renal tissue injury in concern with IRI.

KW - Metabolism

KW - Kidney

KW - MRI

M3 - Poster

T2 - Experimental biology 2016

Y2 - 2 April 2016 through 6 April 2016

ER -