Improving Translational Research in Sex-specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • C Perrino, Federico II University Hospital
  • ,
  • P Ferdinandy, Semmelweis Univ, Semmelweis University, Heart & Vasc Ctr
  • ,
  • H E Bøtker
  • B J J M Brundel, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • ,
  • P Collins, Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, UK.
  • ,
  • S M Davidson, University College London, London
  • ,
  • H M den Ruijter, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr
  • ,
  • F B Engel, Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland.
  • ,
  • E Gerdts, Department of Biology, University of Bergen, Bergen, Norway; Sars International Centre, Uni Research, University of Bergen, Bergen, Norway.
  • ,
  • H Girao, Coimbra Herbarium, University of Coimbra
  • ,
  • M Gyöngyösi, Medical University Vienna, Vienna
  • ,
  • D J Hausenloy, Health Services and Systems Research, Duke-NUS (National University of Singapore) Medical School, Singapore.
  • ,
  • S Lecour, Univ Cape Town, University of Cape Town, Zool Dept
  • ,
  • R Madonna, Department for Clinical and Experimental Medicine, University of Pisa, Endocrine Unit 2, University Hospital of Pisa, Pisa, Italy.
  • ,
  • M Marber, King's College London BHF Centre, The Rayne Institute, St. Thomas' Hospital, London, UK.
  • ,
  • E Murphy, The Bethesda Health Research Center, Bethesda, MD, USA.
  • ,
  • M Pesce, Italy
  • ,
  • V Regitz-Zagrosek, Berlin Institute of Gender in Medicine
  • ,
  • J P G Sluijter, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr
  • ,
  • S Steffens, Ludwig-Maximilians-University 1 Munich and German Centre for Cardiovascular Research (DZHK)
  • ,
  • C Gollmann-Tepeköylü, Univ Klin Innsbruck, Medical University of Innsbruck
  • ,
  • L W Van Laake, Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands; Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: ent-research@umcutrecht.nl.
  • ,
  • S Van Linthout, Department of Internal Medicine and Cardiology, Charité University Medicine Berlin-Campus Virchow Klinikum, Berlin, Germany13Department of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
  • ,
  • R Schulz, Justus Liebig Univ Giessen, Justus Liebig University Giessen, Dept Dermatol & Allergol, Univ Med Ctr Giessen & Marburg
  • ,
  • K Ytrehus, UiT Arctic Univ Norway, UiT The Arctic University of Tromso, Inst Arctic & Marine Biol

Ischemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex however affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, diagnosis as well as treatment and outcome. Several diseases or risk factors frequently associated with IHD can modify cellular signalling cascades, thus affecting ischemia/reperfusion injury as well as responses to cardioprotective interventions. Importantly, the prevalence and impact of risk factors and several comorbidities differ between males and females, and their effects on IHD development and prognosis might differ according to sex. The cellular and molecular mechanisms underlying these differences are still poorly understood, and their identification might have important translational implications in the prediction or prevention of risk of IHD in men and women. Despite this, most experimental studies on IHD are still undertaken in animal models in the absence of risk factors and comorbidities, and assessment of potential sex-specific differences are largely missing. This ESC WG Position Paper will discuss: a) the importance of sex as a biological variable in cardiovascular research, b) major biological mechanisms underlying sex-related differences relevant to IHD risk factors and comorbidities, c) prospects and pitfalls of preclinical models to investigate these associations, and finally d) will provide recommendations to guide future research. Although gender differences also affect IHD risk in the clinical setting, they will not be discussed in detail here.

OriginalsprogEngelsk
TidsskriftCardiovascular Research
Vol/bind117
Nummer2
Sider (fra-til)367-385
Antal sider19
ISSN0008-6363
DOI
StatusUdgivet - jan. 2021

Bibliografisk note

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions please email: journals.permissions@oup.com.

Se relationer på Aarhus Universitet Citationsformater

ID: 191457064