Improved prediction of mortality by combinations of inflammatory markers and standard clinical scores in patients with acute-on-chronic liver failure and acute decompensation

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Henning Grønbæk
  • Holger Jon Møller
  • Faouzi Saliba, Hopital Paul-Brousse
  • ,
  • Stefan Zeuzem, Goethe University Frankfurt
  • ,
  • Agustin Albillos, Hospital Ramon y Cajal
  • ,
  • Xavier Ariza, University of Barcelona
  • ,
  • Isabel Graupera, University of Barcelona
  • ,
  • Elsa Solà, University of Barcelona
  • ,
  • Alex Amoros, European Foundation for the Study of Chronic Liver Failure (EF-CLIF)
  • ,
  • Marco Pavesi, European Foundation for the Study of Chronic Liver Failure (EF-CLIF)
  • ,
  • Lars Bossen
  • Rajiv Jalan, University College London
  • ,
  • Pere Gines, University of Barcelona
  • ,
  • Vicente Arroyo, European Foundation for the Study of Chronic Liver Failure (EF-CLIF)

Background and Aim: Acute-on-chronic liver failure (ACLF) is a sinister prognosis, and there is a need for accurate biomarkers and scoring systems to better characterize ACLF patients and predict prognosis. Systemic inflammation and renal failure are hallmarks in ACLF disease development and progression. We hypothesized that the combination of specific inflammatory markers in combination with clinical scores are better predictors of survival than the originally developed CLIF-C acute decompensation (AD) and CLIF-C ACLF scores. Methods: We reevaluated all previously measured inflammatory markers in 522 patients from the CANONIC study, 342 without and 180 with ACLF. We used the Harrell's C-index to determine the best marker alone or in combination with the original scores and calculated new scores for prediction of mortality in the original CANONIC cohort. Results: The best markers to predict 90-day mortality in patients without ACLF were the plasma macrophage activation markers soluble (s)CD163 and mannose receptor (sMR). Urinary neutrophil gelatinase associated lipocalin (UNGAL) and sCD163 were predictors for 28-day mortality in patients with ACLF. The newly developed CLIF-C AD + sMR score in patients without ACLF improved 90-day mortality prediction compared with the original CLIF-C AD score (C-index 0.82 [0.78–0.86] vs 0.74 [0.70–0.78, P = 0.004]). Further, the new CLIF-C ACLF + sCD163 + UNGAL improved the original CLIF-C ACLF score for 28-day mortality (0.85 [0.79–0.91] vs 0.75 [0.70–0.80], P = 0.039). Conclusions: The capability of these inflammatory markers to improve the original prognostic scores in cirrhosis patients without and with ACLF points to a key role of macrophage activation and inflammation in the development and progression of AD and ACLF.

OriginalsprogEngelsk
TidsskriftJournal of Gastroenterology and Hepatology (Australia)
Antal sider9
ISSN0815-9319
DOI
StatusE-pub ahead of print - 1 jan. 2020

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