Impact of spectral body imaging in patients suspected for occult cancer: a prospective study of 503 patients

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Impact of spectral body imaging in patients suspected for occult cancer : a prospective study of 503 patients. / Andersen, Michael Brun; Ebbesen, Dyveke; Thygesen, Jesper; Kruis, Matthijs; Rasmussen, Finn.

I: European Radiology, Bind 30, Nr. 10, 10.2020, s. 5539-5550.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Andersen, MB, Ebbesen, D, Thygesen, J, Kruis, M & Rasmussen, F 2020, 'Impact of spectral body imaging in patients suspected for occult cancer: a prospective study of 503 patients', European Radiology, bind 30, nr. 10, s. 5539-5550. https://doi.org/10.1007/s00330-020-06878-7

APA

CBE

MLA

Vancouver

Author

Andersen, Michael Brun ; Ebbesen, Dyveke ; Thygesen, Jesper ; Kruis, Matthijs ; Rasmussen, Finn. / Impact of spectral body imaging in patients suspected for occult cancer : a prospective study of 503 patients. I: European Radiology. 2020 ; Bind 30, Nr. 10. s. 5539-5550.

Bibtex

@article{55b9aafb32994da99dc5cfe649fbd107,
title = "Impact of spectral body imaging in patients suspected for occult cancer: a prospective study of 503 patients",
abstract = "Objectives: To investigate the diagnostic impact and performance of spectral dual-layer detector CT in the detection and characterization of cancer compared to conventional CE-CT. Methods: In a national workup program for occult cancer, 503 patients (286 females and 217 males) were prospectively enrolled for a contrast-enhanced spectral CT scan. The readings were performed with and without spectral data available. A minimum of 3 months between interpretations was implemented to minimize recall bias. The sequence of reads for the individual patient was randomized. Readers were blinded for patient identifiers and clinical outcome. Two radiologists with 9 and 33 years of experience performed the readings in consensus. If disagreement, a third radiologist with 11 years of experience determined the outcome of the reading Results: Significantly more cancer findings were identified on the spectral reading. In 73 cases of proven cancer, we found a sensitivity of 89% vs 77% and a specificity of 77% vs 83% on spectral CT compared to conventional CT. A slight increase in reading time in spectral images of 82 s was found (382 vs 300, p < 0.001). For all cystic lesions, the perceived diagnostic certainty increased from 30% being completely certain to 96% most pronounced in the kidney, liver, thyroid, and ovaries. And adding the spectral information to the reading gave a decrease in follow-up examination for diagnostic certainty (0.25 vs 0.81 per reading, p < 0.001). Conclusion: The use of contrast-enhanced spectral CT increases the confidence of the radiologists in correct characterization of various lesions and minimizes the need for supplementary examinations. Key Points: • Spectral CT is associated with a higher sensitivity, but a slightly lower specificity compared to conventional CT. • Spectral CT increases the confidence of the radiologists. • The need for supplementary examinations is decreased, with only a slight increase in reading times.",
keywords = "Abdomen, Clinical oncology, Helical CT, Thorax",
author = "Andersen, {Michael Brun} and Dyveke Ebbesen and Jesper Thygesen and Matthijs Kruis and Finn Rasmussen",
year = "2020",
month = oct,
doi = "10.1007/s00330-020-06878-7",
language = "English",
volume = "30",
pages = "5539--5550",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Impact of spectral body imaging in patients suspected for occult cancer

T2 - a prospective study of 503 patients

AU - Andersen, Michael Brun

AU - Ebbesen, Dyveke

AU - Thygesen, Jesper

AU - Kruis, Matthijs

AU - Rasmussen, Finn

PY - 2020/10

Y1 - 2020/10

N2 - Objectives: To investigate the diagnostic impact and performance of spectral dual-layer detector CT in the detection and characterization of cancer compared to conventional CE-CT. Methods: In a national workup program for occult cancer, 503 patients (286 females and 217 males) were prospectively enrolled for a contrast-enhanced spectral CT scan. The readings were performed with and without spectral data available. A minimum of 3 months between interpretations was implemented to minimize recall bias. The sequence of reads for the individual patient was randomized. Readers were blinded for patient identifiers and clinical outcome. Two radiologists with 9 and 33 years of experience performed the readings in consensus. If disagreement, a third radiologist with 11 years of experience determined the outcome of the reading Results: Significantly more cancer findings were identified on the spectral reading. In 73 cases of proven cancer, we found a sensitivity of 89% vs 77% and a specificity of 77% vs 83% on spectral CT compared to conventional CT. A slight increase in reading time in spectral images of 82 s was found (382 vs 300, p < 0.001). For all cystic lesions, the perceived diagnostic certainty increased from 30% being completely certain to 96% most pronounced in the kidney, liver, thyroid, and ovaries. And adding the spectral information to the reading gave a decrease in follow-up examination for diagnostic certainty (0.25 vs 0.81 per reading, p < 0.001). Conclusion: The use of contrast-enhanced spectral CT increases the confidence of the radiologists in correct characterization of various lesions and minimizes the need for supplementary examinations. Key Points: • Spectral CT is associated with a higher sensitivity, but a slightly lower specificity compared to conventional CT. • Spectral CT increases the confidence of the radiologists. • The need for supplementary examinations is decreased, with only a slight increase in reading times.

AB - Objectives: To investigate the diagnostic impact and performance of spectral dual-layer detector CT in the detection and characterization of cancer compared to conventional CE-CT. Methods: In a national workup program for occult cancer, 503 patients (286 females and 217 males) were prospectively enrolled for a contrast-enhanced spectral CT scan. The readings were performed with and without spectral data available. A minimum of 3 months between interpretations was implemented to minimize recall bias. The sequence of reads for the individual patient was randomized. Readers were blinded for patient identifiers and clinical outcome. Two radiologists with 9 and 33 years of experience performed the readings in consensus. If disagreement, a third radiologist with 11 years of experience determined the outcome of the reading Results: Significantly more cancer findings were identified on the spectral reading. In 73 cases of proven cancer, we found a sensitivity of 89% vs 77% and a specificity of 77% vs 83% on spectral CT compared to conventional CT. A slight increase in reading time in spectral images of 82 s was found (382 vs 300, p < 0.001). For all cystic lesions, the perceived diagnostic certainty increased from 30% being completely certain to 96% most pronounced in the kidney, liver, thyroid, and ovaries. And adding the spectral information to the reading gave a decrease in follow-up examination for diagnostic certainty (0.25 vs 0.81 per reading, p < 0.001). Conclusion: The use of contrast-enhanced spectral CT increases the confidence of the radiologists in correct characterization of various lesions and minimizes the need for supplementary examinations. Key Points: • Spectral CT is associated with a higher sensitivity, but a slightly lower specificity compared to conventional CT. • Spectral CT increases the confidence of the radiologists. • The need for supplementary examinations is decreased, with only a slight increase in reading times.

KW - Abdomen

KW - Clinical oncology

KW - Helical CT

KW - Thorax

UR - http://www.scopus.com/inward/record.url?scp=85085131859&partnerID=8YFLogxK

U2 - 10.1007/s00330-020-06878-7

DO - 10.1007/s00330-020-06878-7

M3 - Journal article

C2 - 32367416

AN - SCOPUS:85085131859

VL - 30

SP - 5539

EP - 5550

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 10

ER -