Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

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Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation. / Bach Knudsen, Knud Erik; Lærke, Helle Nygaard; Hedemann, Mette Skou; Nielsen, Tina Skau; Ingerslev, Anne Krog; Gundelund Nielsen, Ditte Søvsø; Theil, Peter Kappel; Purup, Stig; Hald, Stine; Schioldan, Anne Grethe; Marco, Maria L.; Gregersen, Søren; Hermansen, Kjeld.

I: Nutrients, Bind 10, Nr. 10, 13.10.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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@article{0c55857d18224a93904df20d0efb0778,
title = "Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation",
abstract = "A major challenge in affluent societies is the increase in disorders related to gut and metabolic health. Chronic over nutrition by unhealthy foods high in energy, fat, and sugar, and low in dietary fibre is a key environmental factor responsible for this development, which may cause local and systemic inflammation. A low intake of dietary fibre is a limiting factor for maintaining a viable and diverse microbiota and production of short-chain fatty acids in the gut. A suppressed production of butyrate is crucial, as this short-chain fatty acid (SCFA) can play a key role not only in colonic health and function but also at the systemic level. At both sites, the mode of action is through mediation of signalling pathways involving nuclear NF-κB and inhibition of histone deacetylase. The intake and composition of dietary fibre modulate production of butyrate in the large intestine. While butyrate production is easily adjustable it is more variable how it influences gut barrier function and inflammatory markers in the gut and periphery. The effect of butyrate seems generally to be more consistent and positive on inflammatory markers related to the gut than on inflammatory markers in the peripheral tissue. This discrepancy may be explained by differences in butyrate concentrations in the gut compared with the much lower concentration at more remote sites.",
keywords = "butyrate, dietary fibre, gut barrier function, gut inflammation, systemic inflammation",
author = "{Bach Knudsen}, {Knud Erik} and L{\ae}rke, {Helle Nygaard} and Hedemann, {Mette Skou} and Nielsen, {Tina Skau} and Ingerslev, {Anne Krog} and {Gundelund Nielsen}, {Ditte S{\o}vs{\o}} and Theil, {Peter Kappel} and Stig Purup and Stine Hald and Schioldan, {Anne Grethe} and Marco, {Maria L.} and S{\o}ren Gregersen and Kjeld Hermansen",
year = "2018",
month = "10",
day = "13",
doi = "10.3390/nu10101499",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

AU - Bach Knudsen, Knud Erik

AU - Lærke, Helle Nygaard

AU - Hedemann, Mette Skou

AU - Nielsen, Tina Skau

AU - Ingerslev, Anne Krog

AU - Gundelund Nielsen, Ditte Søvsø

AU - Theil, Peter Kappel

AU - Purup, Stig

AU - Hald, Stine

AU - Schioldan, Anne Grethe

AU - Marco, Maria L.

AU - Gregersen, Søren

AU - Hermansen, Kjeld

PY - 2018/10/13

Y1 - 2018/10/13

N2 - A major challenge in affluent societies is the increase in disorders related to gut and metabolic health. Chronic over nutrition by unhealthy foods high in energy, fat, and sugar, and low in dietary fibre is a key environmental factor responsible for this development, which may cause local and systemic inflammation. A low intake of dietary fibre is a limiting factor for maintaining a viable and diverse microbiota and production of short-chain fatty acids in the gut. A suppressed production of butyrate is crucial, as this short-chain fatty acid (SCFA) can play a key role not only in colonic health and function but also at the systemic level. At both sites, the mode of action is through mediation of signalling pathways involving nuclear NF-κB and inhibition of histone deacetylase. The intake and composition of dietary fibre modulate production of butyrate in the large intestine. While butyrate production is easily adjustable it is more variable how it influences gut barrier function and inflammatory markers in the gut and periphery. The effect of butyrate seems generally to be more consistent and positive on inflammatory markers related to the gut than on inflammatory markers in the peripheral tissue. This discrepancy may be explained by differences in butyrate concentrations in the gut compared with the much lower concentration at more remote sites.

AB - A major challenge in affluent societies is the increase in disorders related to gut and metabolic health. Chronic over nutrition by unhealthy foods high in energy, fat, and sugar, and low in dietary fibre is a key environmental factor responsible for this development, which may cause local and systemic inflammation. A low intake of dietary fibre is a limiting factor for maintaining a viable and diverse microbiota and production of short-chain fatty acids in the gut. A suppressed production of butyrate is crucial, as this short-chain fatty acid (SCFA) can play a key role not only in colonic health and function but also at the systemic level. At both sites, the mode of action is through mediation of signalling pathways involving nuclear NF-κB and inhibition of histone deacetylase. The intake and composition of dietary fibre modulate production of butyrate in the large intestine. While butyrate production is easily adjustable it is more variable how it influences gut barrier function and inflammatory markers in the gut and periphery. The effect of butyrate seems generally to be more consistent and positive on inflammatory markers related to the gut than on inflammatory markers in the peripheral tissue. This discrepancy may be explained by differences in butyrate concentrations in the gut compared with the much lower concentration at more remote sites.

KW - butyrate

KW - dietary fibre

KW - gut barrier function

KW - gut inflammation

KW - systemic inflammation

UR - http://www.scopus.com/inward/record.url?scp=85054888648&partnerID=8YFLogxK

U2 - 10.3390/nu10101499

DO - 10.3390/nu10101499

M3 - Review

C2 - 30322146

AN - SCOPUS:85054888648

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

ER -