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IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis

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  • H. Öhman, Danmark
  • A Tiitinen, Danmark
  • M. Halttunen, Danmark
  • Svend Birkelund, Danmark
  • Gunna Christiansen
  • P. Koskela, Danmark
  • M. Lehtinen, Danmark
  • J. Paavonen, Danmark
  • H.-M. Surcel, Danmark
  • Institut for Medicinsk Mikrobiologi og Immunologi

Chlamydia trachomatis infection induces an inflammatory response that is crucial in resolving acute infection but may also play a key role in the pathogenesis of C trachomatis associated infertility. The immune response is linked to cytokine secretion pattern which is influenced by the host genetic background. To study a relationship between interleukin-10 (IL-10) promoter -1082 polymorphism and cell-mediated immune response during C trachomatis infection in vitro, lymphocyte proliferation and cytokine (IL-10, IFN-gamma, TNF-alpha, IL-2, IL-4 and IL-5) secretion were analysed in subjects with different IL-10 genotypes. Enhanced IL-10 secretion and reduced antigen-specific lymphocyte proliferative and IFN-gamma responses were found in subjects with IL-10 -1082 GG genotype when compared to those with -1082 AA genotype. CD14+ monocytes were main source of IL-10 indicating that these cells are important regulators of the antigen-specific cell-mediated responses during active C trachomatis infection. We conclude that impaired cell-mediated response to C trachomatis is associated with IL-10 genotype in subjects with high IL-10 producing capacity. A comparison of immune markers between subjects with a history of noncomplicated and complicated infection is needed to further understand the confounding factors associated with the development of C trachomatis associated sequelae.Genes and Immunity (2006) 7, 243-249. doi:10.1038/sj.gene.6364293; published online 9 March 2006.

OriginalsprogEngelsk
TidsskriftGenes and Immunity
Vol/bind7
Sider (fra-til)243-249
ISSN1466-4879
StatusUdgivet - 2006

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