IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites

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  • Ervinas Gaidamauskas, Danmark
  • Claus Gyrup Nielsen
  • ,
  • Henning Bünsow Boldt, Danmark
  • Vivien R Schack
  • Michael Toft Overgaard, Institut for Kemi og Bioteknologi, Danmark
  • Lisbeth S Laursen, Danmark
  • Claus Oxvig
Pregnancy-associated plasma protein-A (PAPP-A) is a local regulator of insulin-like growth factor (IGF) bioavailability in physiological systems, but many structural and functional aspects of the metzincin metalloproteinase remain to be elucidated. PAPP-A cleaves IGF binding protein (IGFBP)-4 and IGFBP-5. Cleavage of IGFBP-4, but not IGFBP-5, depends on the binding of IGF before proteolysis by PAPP-A can occur. The paralogue PAPP-A2 has two substrates among the six IGFBPs: IGFBP-3 and IGFBP-5.
OriginalsprogEngelsk
TidsskriftBBA General Subjects
Vol/bind1830
Nummer3
Sider (fra-til)2701-2709
Antal sider9
ISSN0304-4165
StatusUdgivet - mar. 2013

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