@article{d4f1adb6e35d418f9ecb9da23f92071e,
title = "IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites",
abstract = "Pregnancy-associated plasma protein-A (PAPP-A) is a local regulator of insulin-like growth factor (IGF) bioavailability in physiological systems, but many structural and functional aspects of the metzincin metalloproteinase remain to be elucidated. PAPP-A cleaves IGF binding protein (IGFBP)-4 and IGFBP-5. Cleavage of IGFBP-4, but not IGFBP-5, depends on the binding of IGF before proteolysis by PAPP-A can occur. The paralogue PAPP-A2 has two substrates among the six IGFBPs: IGFBP-3 and IGFBP-5.",
keywords = "Amino Acid Sequence, Binding Sites, Female, HEK293 Cells, Humans, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 5, Models, Molecular, Molecular Sequence Data, Pregnancy, Pregnancy-Associated Plasma Protein-A, Protein Binding, Protein Interaction Domains and Motifs, Proteolysis, Recombinant Fusion Proteins, Somatomedins, Substrate Specificity, Transfection",
author = "Ervinas Gaidamauskas and Nielsen, {Claus Gyrup} and Boldt, {Henning B{\"u}nsow} and Schack, {Vivien R} and Overgaard, {Michael Toft} and Laursen, {Lisbeth S} and Claus Oxvig",
year = "2013",
month = mar,
language = "English",
volume = "1830",
pages = "2701--2709",
journal = "BBA General Subjects",
issn = "0304-4165",
publisher = "Elsevier B.V.",
number = "3",
}