IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites

Ervinas Gaidamauskas, Claus Gyrup Nielsen, Henning Bünsow Boldt, Vivien R Schack, Michael Toft Overgaard, Lisbeth S Laursen, Claus Oxvig

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

23 Citationer (Scopus)

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a local regulator of insulin-like growth factor (IGF) bioavailability in physiological systems, but many structural and functional aspects of the metzincin metalloproteinase remain to be elucidated. PAPP-A cleaves IGF binding protein (IGFBP)-4 and IGFBP-5. Cleavage of IGFBP-4, but not IGFBP-5, depends on the binding of IGF before proteolysis by PAPP-A can occur. The paralogue PAPP-A2 has two substrates among the six IGFBPs: IGFBP-3 and IGFBP-5.
OriginalsprogEngelsk
TidsskriftBBA General Subjects
Vol/bind1830
Nummer3
Sider (fra-til)2701-2709
Antal sider9
ISSN0304-4165
StatusUdgivet - mar. 2013

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