IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study

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  • G. Doekes, Institute for Risk Assessment Sciences, University Utrecht, Holland
  • Preben Larsen, Department of Occupational and Environmental Medicine, OUH, Danmark
  • Torben Sigsgaard
  • Jesper Bælum, Department of Occupational and Environmental Medicine, OUH, Danmark
  • Afdeling for Miljø- og Arbejdsmedicin
BACKGROUND: The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS: Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS: Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS: Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.
TidsskriftAmerican Journal of Industrial Medicine
Sider (fra-til)404-407
Antal sider4
StatusUdgivet - okt. 2004

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