Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

Benedicte M W Johannsen; Janne Tidselbak Larsen; Xiaoqin Liu; Kathrine Bang Madsen; Merete Lund Maegbaek; Clara Albiñana; Veerle Bergink; Thomas M Laursen; Bodil H Bech; Preben Bo Mortensen; Merete Nordentoft; Anders D Børglum; Thomas Werge; David M Hougaard; Esben Agerbo; Liselotte Vogdrup Petersen; Trine Munk-Olsen

doi:10.1111/acps.13622

Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

Benedicte M W Johannsen, Janne Tidselbak Larsen, Xiaoqin Liu, Kathrine Bang Madsen, Merete Lund Maegbaek, Clara Albiñana, Veerle Bergink, Thomas M Laursen, Bodil H Bech, Preben Bo Mortensen, Merete Nordentoft, Anders D Børglum, Thomas Werge, David M Hougaard, Esben Agerbo, Liselotte Vogdrup Petersen, Trine Munk-Olsen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

BACKGROUND: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability.

METHODS: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981-1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions.

RESULTS: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%-7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%-27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%-38.4%) for PPE.

CONCLUSIONS: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.

Originalsprog	Engelsk
Artikelnummer	13622
Tidsskrift	Acta Psychiatrica Scandinavica
Vol/bind	150
Nummer	5
Sider (fra-til)	385-394
Antal sider	10
ISSN	0001-690X
DOI	https://doi.org/10.1111/acps.13622
Status	Udgivet - nov. 2024

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Johannsen, B. M. W., Larsen, J. T., Liu, X., Madsen, K. B., Maegbaek, M. L., Albiñana, C., Bergink, V., Laursen, T. M., Bech, B. H., Mortensen, P. B., Nordentoft, M., Børglum, A. D., Werge, T., Hougaard, D. M., Agerbo, E., Petersen, L. V., & Munk-Olsen, T. (2024). Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. Acta Psychiatrica Scandinavica, 150(5), 385-394. Artikel 13622. https://doi.org/10.1111/acps.13622

@article{d7586c884d6849e4ba7353541b45afd6,

title = "Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability",

abstract = "BACKGROUND: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability.METHODS: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981-1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions.RESULTS: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%-7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%-27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%-38.4%) for PPE.CONCLUSIONS: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.",

keywords = "epidemiology, perinatal mental health",

author = "Johannsen, {Benedicte M W} and Larsen, {Janne Tidselbak} and Xiaoqin Liu and Madsen, {Kathrine Bang} and Maegbaek, {Merete Lund} and Clara Albi{\~n}ana and Veerle Bergink and Laursen, {Thomas M} and Bech, {Bodil H} and Mortensen, {Preben Bo} and Merete Nordentoft and B{\o}rglum, {Anders D} and Thomas Werge and Hougaard, {David M} and Esben Agerbo and Petersen, {Liselotte Vogdrup} and Trine Munk-Olsen",

note = "{\textcopyright} 2023 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.",

year = "2024",

month = nov,

doi = "10.1111/acps.13622",

language = "English",

volume = "150",

pages = "385--394",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

}

Johannsen, BMW , Larsen, JT , Liu, X , Madsen, KB , Maegbaek, ML , Albiñana, C, Bergink, V, Laursen, TM , Bech, BH , Mortensen, PB, Nordentoft, M, Børglum, AD, Werge, T, Hougaard, DM, Agerbo, E , Petersen, LV & Munk-Olsen, T 2024, 'Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability', Acta Psychiatrica Scandinavica, bind 150, nr. 5, 13622, s. 385-394. https://doi.org/10.1111/acps.13622

Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. / Johannsen, Benedicte M W ; Larsen, Janne Tidselbak ; Liu, Xiaoqin et al.
I: Acta Psychiatrica Scandinavica, Bind 150, Nr. 5, 13622, 11.2024, s. 385-394.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Identification of women at high risk of postpartum psychiatric episodes

T2 - A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

AU - Johannsen, Benedicte M W

AU - Larsen, Janne Tidselbak

AU - Liu, Xiaoqin

AU - Madsen, Kathrine Bang

AU - Maegbaek, Merete Lund

AU - Albiñana, Clara

AU - Bergink, Veerle

AU - Laursen, Thomas M

AU - Bech, Bodil H

AU - Mortensen, Preben Bo

AU - Nordentoft, Merete

AU - Børglum, Anders D

AU - Werge, Thomas

AU - Hougaard, David M

AU - Agerbo, Esben

AU - Petersen, Liselotte Vogdrup

AU - Munk-Olsen, Trine

PY - 2024/11

Y1 - 2024/11

N2 - BACKGROUND: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability.METHODS: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981-1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions.RESULTS: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%-7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%-27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%-38.4%) for PPE.CONCLUSIONS: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.

AB - BACKGROUND: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability.METHODS: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981-1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions.RESULTS: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%-7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%-27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%-38.4%) for PPE.CONCLUSIONS: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.

KW - epidemiology

KW - perinatal mental health

UR - http://www.scopus.com/inward/record.url?scp=85174633399&partnerID=8YFLogxK

U2 - 10.1111/acps.13622

DO - 10.1111/acps.13622

M3 - Journal article

C2 - 37871908

SN - 0001-690X

VL - 150

SP - 385

EP - 394

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 5

M1 - 13622

ER -

Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

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