Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families

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  • V R Gregersen, Danmark
  • K K Sørensen
  • O F Christensen
  • Ingela Velander, Videncenter for Svineproduktion, Axelborg, Danmark
  • M E Busch, Danish Agriculture & Food Counsil, Danmark
  • R K K Vingborg, Danmark
  • I H Velander, Danish Agriculture & Food Council, Danmark
  • M S Lund
  • C Bendixen
  • GBI Afdelingsfunktion
  • Biostatistik
  • Molekylær Genetik og Systembiologi
  • Institut for Genetik og Bioteknologi
Pleuropneumonia is a major problem in pig production. At the time of slaughter, chronic pleuritis (CP) developed from pleuropneumonia is a common finding, and breeding for a reduced incidence of CP using marker-assisted selection (MAS) would be advantageous. Before applying MAS, quantitative trait loci (QTL) or markers associated with the prevalence of CP should be identified. In this study, 7470 pigs from crosses between 12 Danish Duroc boars and 604 sows (Danish Landrace × Danish Large White) were evaluated for CP located on the dorso-caudal part of the lungs. Quantitative trait loci were identified within boar families using both a Binomial logistic regression method and a chi-square test of association. Significant QTL for CP were detected on Sus scrofa chromosomes (SSC) 2, 8, 12, 13, 14 and 18 using both methods. One QTL on SSC 8 was also detected across families. For the QTL identified within families, the odds-ratio of having CP was approximately twice as high for the unfavourable allele compared to the favourable one. These QTL and closely linked markers show promise for the development of gene-specific markers associated with a reduced incidence of CP located on the dorso-caudal part of the lungs.
Udgivelsesdato: October 2010
OriginalsprogEngelsk
TidsskriftJournal of Animal Science
Vol/bind41
Nummer5
Sider (fra-til)509-514
Antal sider6
ISSN0021-8812
DOI
StatusUdgivet - 2010

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