Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families

V R Gregersen; K K Sørensen; O F Christensen; Ingela Velander; M E Busch; R K K Vingborg; I H Velander; M S Lund; C Bendixen

doi:10.1111/j.1365-2052.2010.02028.x

Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families

V R Gregersen, K K Sørensen, O F Christensen, Ingela Velander, M E Busch, R K K Vingborg, I H Velander, M S Lund, C Bendixen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Pleuropneumonia is a major problem in pig production. At the time of slaughter, chronic pleuritis (CP) developed from pleuropneumonia is a common finding, and breeding for a reduced incidence of CP using marker-assisted selection (MAS) would be advantageous. Before applying MAS, quantitative trait loci (QTL) or markers associated with the prevalence of CP should be identified. In this study, 7470 pigs from crosses between 12 Danish Duroc boars and 604 sows (Danish Landrace × Danish Large White) were evaluated for CP located on the dorso-caudal part of the lungs. Quantitative trait loci were identified within boar families using both a Binomial logistic regression method and a chi-square test of association. Significant QTL for CP were detected on Sus scrofa chromosomes (SSC) 2, 8, 12, 13, 14 and 18 using both methods. One QTL on SSC 8 was also detected across families. For the QTL identified within families, the odds-ratio of having CP was approximately twice as high for the unfavourable allele compared to the favourable one. These QTL and closely linked markers show promise for the development of gene-specific markers associated with a reduced incidence of CP located on the dorso-caudal part of the lungs.
Udgivelsesdato: October 2010

Originalsprog	Engelsk
Tidsskrift	Journal of Animal Science
Vol/bind	41
Nummer	5
Sider (fra-til)	509-514
Antal sider	6
ISSN	0021-8812
DOI	https://doi.org/10.1111/j.1365-2052.2010.02028.x
Status	Udgivet - 2010

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10.1111/j.1365-2052.2010.02028.x

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title = "Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families",

abstract = "Pleuropneumonia is a major problem in pig production. At the time of slaughter, chronic pleuritis (CP) developed from pleuropneumonia is a common finding, and breeding for a reduced incidence of CP using marker-assisted selection (MAS) would be advantageous. Before applying MAS, quantitative trait loci (QTL) or markers associated with the prevalence of CP should be identified. In this study, 7470 pigs from crosses between 12 Danish Duroc boars and 604 sows (Danish Landrace × Danish Large White) were evaluated for CP located on the dorso-caudal part of the lungs. Quantitative trait loci were identified within boar families using both a Binomial logistic regression method and a chi-square test of association. Significant QTL for CP were detected on Sus scrofa chromosomes (SSC) 2, 8, 12, 13, 14 and 18 using both methods. One QTL on SSC 8 was also detected across families. For the QTL identified within families, the odds-ratio of having CP was approximately twice as high for the unfavourable allele compared to the favourable one. These QTL and closely linked markers show promise for the development of gene-specific markers associated with a reduced incidence of CP located on the dorso-caudal part of the lungs.",

keywords = "Actinobacillus pleuropneumoniae, lung lesions, pig breeding, pleuropneumonia, single nucleotide polymorphism, Sus scrofa, swine respiratory disease",

author = "Gregersen, {V R} and S{\o}rensen, {K K} and Christensen, {O F} and Ingela Velander and Busch, {M E} and Vingborg, {R K K} and Velander, {I H} and Lund, {M S} and C Bendixen",

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TY - JOUR

T1 - Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families

AU - Gregersen, V R

AU - Sørensen, K K

AU - Christensen, O F

AU - Velander, Ingela

AU - Busch, M E

AU - Vingborg, R K K

AU - Velander, I H

AU - Lund, M S

AU - Bendixen, C

PY - 2010

Y1 - 2010

N2 - Pleuropneumonia is a major problem in pig production. At the time of slaughter, chronic pleuritis (CP) developed from pleuropneumonia is a common finding, and breeding for a reduced incidence of CP using marker-assisted selection (MAS) would be advantageous. Before applying MAS, quantitative trait loci (QTL) or markers associated with the prevalence of CP should be identified. In this study, 7470 pigs from crosses between 12 Danish Duroc boars and 604 sows (Danish Landrace × Danish Large White) were evaluated for CP located on the dorso-caudal part of the lungs. Quantitative trait loci were identified within boar families using both a Binomial logistic regression method and a chi-square test of association. Significant QTL for CP were detected on Sus scrofa chromosomes (SSC) 2, 8, 12, 13, 14 and 18 using both methods. One QTL on SSC 8 was also detected across families. For the QTL identified within families, the odds-ratio of having CP was approximately twice as high for the unfavourable allele compared to the favourable one. These QTL and closely linked markers show promise for the development of gene-specific markers associated with a reduced incidence of CP located on the dorso-caudal part of the lungs.

AB - Pleuropneumonia is a major problem in pig production. At the time of slaughter, chronic pleuritis (CP) developed from pleuropneumonia is a common finding, and breeding for a reduced incidence of CP using marker-assisted selection (MAS) would be advantageous. Before applying MAS, quantitative trait loci (QTL) or markers associated with the prevalence of CP should be identified. In this study, 7470 pigs from crosses between 12 Danish Duroc boars and 604 sows (Danish Landrace × Danish Large White) were evaluated for CP located on the dorso-caudal part of the lungs. Quantitative trait loci were identified within boar families using both a Binomial logistic regression method and a chi-square test of association. Significant QTL for CP were detected on Sus scrofa chromosomes (SSC) 2, 8, 12, 13, 14 and 18 using both methods. One QTL on SSC 8 was also detected across families. For the QTL identified within families, the odds-ratio of having CP was approximately twice as high for the unfavourable allele compared to the favourable one. These QTL and closely linked markers show promise for the development of gene-specific markers associated with a reduced incidence of CP located on the dorso-caudal part of the lungs.

KW - Actinobacillus pleuropneumoniae

KW - lung lesions

KW - pig breeding

KW - pleuropneumonia

KW - single nucleotide polymorphism

KW - Sus scrofa

KW - swine respiratory disease

U2 - 10.1111/j.1365-2052.2010.02028.x

DO - 10.1111/j.1365-2052.2010.02028.x

M3 - Journal article

C2 - 20412128

SN - 0021-8812

VL - 41

SP - 509

EP - 514

JO - Journal of Animal Science

JF - Journal of Animal Science

IS - 5

ER -

Identification of QTL for dorso-caudal chronic pleuritis in 12 crossbred porcine families

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