Aarhus Universitets segl

Hypothalamic projections to the optic tectum in larval zebrafish

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Lucy A. Heap, University of Queensland
  • ,
  • Gilles C. Vanwalleghem
  • Andrew W. Thompson, University of Queensland
  • ,
  • Itia Favre-Bulle, University of Queensland
  • ,
  • Halina Rubinsztein-Dunlop, University of Queensland
  • ,
  • Ethan K. Scott, University of Queensland

The optic tectum of larval zebrafish is an important model for understanding visual processing in vertebrates. The tectum has been traditionally viewed as dominantly visual, with a majority of studies focusing on the processes by which tectal circuits receive and process retinally-derived visual information. Recently, a handful of studies have shown a much more complex role for the optic tectum in larval zebrafish, and anatomical and functional data from these studies suggest that this role extends beyond the visual system, and beyond the processing of exclusively retinal inputs. Consistent with this evolving view of the tectum, we have used a Gal4 enhancer trap line to identify direct projections from rostral hypothalamus (RH) to the tectal neuropil of larval zebrafish. These projections ramify within the deepest laminae of the tectal neuropil, the stratum album centrale (SAC)/stratum griseum periventriculare (SPV), and also innervate strata distinct from those innervated by retinal projections. Using optogenetic stimulation of the hypothalamic projection neurons paired with calcium imaging in the tectum, we find rebound firing in tectal neurons consistent with hypothalamic inhibitory input. Our results suggest that tectal processing in larval zebrafish is modulated by hypothalamic inhibitory inputs to the deep tectal neuropil.

TidsskriftFrontiers in Neuroanatomy
StatusUdgivet - 17 jan. 2018
Eksternt udgivetJa

Bibliografisk note

Publisher Copyright:
© 2018 Heap, Vanwalleghem, Thompson, Favre-Bulle, Rubinsztein-Dunlop and Scott.

Se relationer på Aarhus Universitet Citationsformater

ID: 221614258