Hypoglycemia in Pregnancies Following Gastric Bypass—a Systematic Review and Meta-analysis

TY - JOUR

T1 - Hypoglycemia in Pregnancies Following Gastric Bypass—a Systematic Review and Meta-analysis

AU - Stentebjerg, Louise L.

AU - Madsen, Lene R.

AU - Støving, René K.

AU - Juhl, Claus B.

AU - Vinter, Christina A.

AU - Andersen, Lise Lotte T.

AU - Renault, Kristina

AU - Jensen, Dorte M.

N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022/6

Y1 - 2022/6

N2 - The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women’s everyday-life using continuous glucose monitoring and mixed meal test. Graphic Abstract: [Figure not available: see fulltext.]

AB - The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women’s everyday-life using continuous glucose monitoring and mixed meal test. Graphic Abstract: [Figure not available: see fulltext.]

KW - Bariatric surgery

KW - Continuous glucose monitoring

KW - Hypoglycemia

KW - Meta-analysis

KW - Mixed meal test

KW - Obesity

KW - Oral glucose tolerance test

KW - Pregnancy

KW - Roux-en-Y gastric bypass

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=85127616921&partnerID=8YFLogxK

U2 - 10.1007/s11695-022-06021-z

DO - 10.1007/s11695-022-06021-z

M3 - Review

C2 - 35332397

AN - SCOPUS:85127616921

SN - 0960-8923

VL - 32

SP - 2047

EP - 2055

JO - Obesity Surgery

JF - Obesity Surgery

IS - 6

ER -