Hyperbaric oxygen therapy reduces renal lactate production

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Hyperbaric oxygen therapy reduces renal lactate production. / Nørlinger, Thomas S; Nielsen, Per Mose; Qi, Haiyun; Mikkelsen, Emmeli; Hansen, Kasper; Schmidt, Nikolaj H; Pedersen, Michael; Agger, Peter; Palm, Fredrik; Laustsen, Christoffer.

I: Physiological Reports, Bind 5, Nr. 6, 03.2017.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{874b973dde024c6c8683e672e3f9c188,
title = "Hyperbaric oxygen therapy reduces renal lactate production",
abstract = "Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well-known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response of HBO is largely unknown. In this study, we investigated the effect of HBO on the intrarenal metabolic alteration in diabetes. Hyperpolarized [1-(13)C]pyruvate MRI was performed to assess intrarenal energy metabolism in normoglycemic controls and short-term (2 weeks) streptozotocin-induced diabetic rats with and without HBO for five consecutive days. HBO therapy blunted intrarenal lactate production, 3 days after the therapy, in both normoglycemic controls and diabetic rats without affecting either lactate dehydrogenase mRNA expression or activity. HBO therapy reduced lactate formation in both normoglycemic and hyperglycemic rats. These findings support hyperpolarized [1-(13)C]pyruvate MRI as a novel method for monitoring HBO therapy via the pyruvate to lactate conversion.",
keywords = "Journal Article",
author = "N{\o}rlinger, {Thomas S} and Nielsen, {Per Mose} and Haiyun Qi and Emmeli Mikkelsen and Kasper Hansen and Schmidt, {Nikolaj H} and Michael Pedersen and Peter Agger and Fredrik Palm and Christoffer Laustsen",
note = "{\textcopyright} 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.",
year = "2017",
month = mar,
doi = "10.14814/phy2.13217",
language = "English",
volume = "5",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Hyperbaric oxygen therapy reduces renal lactate production

AU - Nørlinger, Thomas S

AU - Nielsen, Per Mose

AU - Qi, Haiyun

AU - Mikkelsen, Emmeli

AU - Hansen, Kasper

AU - Schmidt, Nikolaj H

AU - Pedersen, Michael

AU - Agger, Peter

AU - Palm, Fredrik

AU - Laustsen, Christoffer

N1 - © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

PY - 2017/3

Y1 - 2017/3

N2 - Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well-known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response of HBO is largely unknown. In this study, we investigated the effect of HBO on the intrarenal metabolic alteration in diabetes. Hyperpolarized [1-(13)C]pyruvate MRI was performed to assess intrarenal energy metabolism in normoglycemic controls and short-term (2 weeks) streptozotocin-induced diabetic rats with and without HBO for five consecutive days. HBO therapy blunted intrarenal lactate production, 3 days after the therapy, in both normoglycemic controls and diabetic rats without affecting either lactate dehydrogenase mRNA expression or activity. HBO therapy reduced lactate formation in both normoglycemic and hyperglycemic rats. These findings support hyperpolarized [1-(13)C]pyruvate MRI as a novel method for monitoring HBO therapy via the pyruvate to lactate conversion.

AB - Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well-known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response of HBO is largely unknown. In this study, we investigated the effect of HBO on the intrarenal metabolic alteration in diabetes. Hyperpolarized [1-(13)C]pyruvate MRI was performed to assess intrarenal energy metabolism in normoglycemic controls and short-term (2 weeks) streptozotocin-induced diabetic rats with and without HBO for five consecutive days. HBO therapy blunted intrarenal lactate production, 3 days after the therapy, in both normoglycemic controls and diabetic rats without affecting either lactate dehydrogenase mRNA expression or activity. HBO therapy reduced lactate formation in both normoglycemic and hyperglycemic rats. These findings support hyperpolarized [1-(13)C]pyruvate MRI as a novel method for monitoring HBO therapy via the pyruvate to lactate conversion.

KW - Journal Article

U2 - 10.14814/phy2.13217

DO - 10.14814/phy2.13217

M3 - Journal article

C2 - 28336821

VL - 5

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 6

ER -