TY - JOUR
T1 - Human serum albumin coated Prussian blue nanoparticles as pH-/thermo-triggered drug delivery vehicles for cancer thermo-chemotherapy
AU - Li, Zhenglin
AU - Hu, Ying
AU - Jiang, Tingting
AU - Howard, Ken
AU - Li, Yonggang
AU - Fan, Xuelei
AU - Sun, Ye
AU - Besenbacher, Flemming
AU - Yu, Miao
PY - 2016
Y1 - 2016
N2 - Constructing novel multimodal antitumor therapeutic nanoagents has attracted tremendous recent attention. In this work, a new drug-delivery vehicle based on human-serum-albumin (HSA)-coated Prussian blue nanoparticles (PB NPs) is synthesized. It is demonstrated that doxorubicin (DOX)/HSA is successfully loaded after in situ polymerization of dopamine onto PB NPs, and the PB@PDA/DOX/HSA NPs are highly compatible and stable in various physiological solutions. The NPs possess strong near-infrared (NIR) absorbance, and excellent capability and stability of photothermal conversion for highly efficient photothermal therapy applications. Furthermore, a bimodal on-demand drug release sensitively triggered by pH or NIR irradiation has been realized, resulting in a significant chemotherapeutic effect due to the preferential uptake and internalization of the NPs by cancer cells. Importantly, the thermochemotherapy efficacy of the NPs has been examined by a cell viability assay, revealing a remarkably superior synergistic anticancer effect over either monotherapy. Such multifunctional drug-delivery systems composed of approved materials may have promising biomedical applications for antitumor therapy. Human-serum-albumin-coated Prussian Blue nanoparticles with pH-/thermosensitive drug release are proposed for cancer thermochemotherapy, showing a remarkably superior synergistic effect. Such new drug-delivery systems made of approved materials may have promising biomedical applications for antitumor therapy.
AB - Constructing novel multimodal antitumor therapeutic nanoagents has attracted tremendous recent attention. In this work, a new drug-delivery vehicle based on human-serum-albumin (HSA)-coated Prussian blue nanoparticles (PB NPs) is synthesized. It is demonstrated that doxorubicin (DOX)/HSA is successfully loaded after in situ polymerization of dopamine onto PB NPs, and the PB@PDA/DOX/HSA NPs are highly compatible and stable in various physiological solutions. The NPs possess strong near-infrared (NIR) absorbance, and excellent capability and stability of photothermal conversion for highly efficient photothermal therapy applications. Furthermore, a bimodal on-demand drug release sensitively triggered by pH or NIR irradiation has been realized, resulting in a significant chemotherapeutic effect due to the preferential uptake and internalization of the NPs by cancer cells. Importantly, the thermochemotherapy efficacy of the NPs has been examined by a cell viability assay, revealing a remarkably superior synergistic anticancer effect over either monotherapy. Such multifunctional drug-delivery systems composed of approved materials may have promising biomedical applications for antitumor therapy. Human-serum-albumin-coated Prussian Blue nanoparticles with pH-/thermosensitive drug release are proposed for cancer thermochemotherapy, showing a remarkably superior synergistic effect. Such new drug-delivery systems made of approved materials may have promising biomedical applications for antitumor therapy.
KW - Prussian blue nanoparticles
KW - drug delivery
KW - photothermal therapy
KW - polydopamine
KW - thermochemotherapy
UR - http://www.scopus.com/inward/record.url?scp=84954543292&partnerID=8YFLogxK
U2 - 10.1002/ppsc.201500189
DO - 10.1002/ppsc.201500189
M3 - Journal article
SN - 0934-0866
VL - 33
SP - 53
EP - 62
JO - Particle & Particle Systems Characterization
JF - Particle & Particle Systems Characterization
IS - 1
ER -