Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Kit Riegels Jørgensen; Søren Høyer; Jakob Kristian Jakobsen; Thor Knak Jensen; Niels Marcussen; Gitte Wrist Lam; Thomas Hasselager; Peter Ole Thind; Birgitte Grønkær Toft; Torben Steiniche; Jørgen Bjerggaard Jensen

doi:10.1080/21681805.2018.1531920

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Kit Riegels Jørgensen, Søren Høyer, Jakob Kristian Jakobsen, Thor Knak Jensen, Niels Marcussen, Gitte Wrist Lam, Thomas Hasselager, Peter Ole Thind, Birgitte Grønkær Toft, Torben Steiniche, Jørgen Bjerggaard Jensen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.

PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.

SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.

RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.

PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.

CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Urology
Vol/bind	52
Nummer	5-6
Sider (fra-til)	371-376
Antal sider	6
ISSN	0036-5599
DOI	https://doi.org/10.1080/21681805.2018.1531920
Status	Udgivet - 2018

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10.1080/21681805.2018.1531920

Citationsformater

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title = "Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study",

abstract = "OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.",

keywords = "Urinary bladder cancer, human papillomavirus, p16ink4a, squamous cell carcinoma",

author = "J{\o}rgensen, {Kit Riegels} and S{\o}ren H{\o}yer and Jakobsen, {Jakob Kristian} and Jensen, {Thor Knak} and Niels Marcussen and {Wrist Lam}, Gitte and Thomas Hasselager and Thind, {Peter Ole} and Toft, {Birgitte Gr{\o}nk{\ae}r} and Torben Steiniche and Jensen, {J{\o}rgen Bjerggaard}",

year = "2018",

doi = "10.1080/21681805.2018.1531920",

language = "English",

volume = "52",

pages = "371--376",

journal = "Scandinavian Journal of Urology",

issn = "0036-5599",

publisher = "Taylor & Francis",

number = "5-6",

}

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study. / Jørgensen, Kit Riegels; Høyer, Søren; Jakobsen, Jakob Kristian et al.
I: Scandinavian Journal of Urology, Bind 52, Nr. 5-6, 2018, s. 371-376.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Human papillomavirus and squamous cell carcinoma of the urinary bladder

T2 - DaBlaCa-10 study

AU - Jørgensen, Kit Riegels

AU - Høyer, Søren

AU - Jakobsen, Jakob Kristian

AU - Jensen, Thor Knak

AU - Marcussen, Niels

AU - Wrist Lam, Gitte

AU - Hasselager, Thomas

AU - Thind, Peter Ole

AU - Toft, Birgitte Grønkær

AU - Steiniche, Torben

AU - Jensen, Jørgen Bjerggaard

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.

AB - OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.

KW - Urinary bladder cancer

KW - human papillomavirus

KW - p16ink4a

KW - squamous cell carcinoma

U2 - 10.1080/21681805.2018.1531920

DO - 10.1080/21681805.2018.1531920

M3 - Journal article

C2 - 30526165

SN - 0036-5599

VL - 52

SP - 371

EP - 376

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

IS - 5-6

ER -

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Abstract

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