@article{9b164f4735954a69987e002098df77e4,
title = "Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem",
abstract = "Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and sound transmission were largely preserved. However, fine-scale synaptic refinement and sharpening of isofrequency bands of cochlear neuron activation upon pure tone stimulation were impaired in Hox2 mutants, resulting in defective sound-frequency discrimination in behavioral tests. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit.",
keywords = "Animals, Animals, Newborn, Audiometry, Pure-Tone, Auditory Pathways/physiology, Auditory Perception/physiology, Basic Helix-Loop-Helix Transcription Factors/genetics, Brain Stem/physiology, Cell Adhesion, Cochlear Nucleus/physiology, Conditioning, Psychological, Fear, Gene Expression Profiling, Glutamates/metabolism, Homeodomain Proteins/genetics, Mice, Mice, Mutant Strains, Mutation/genetics, Neurons/metabolism, Organogenesis/genetics, Synapses/metabolism, Synaptic Transmission/physiology, Transcription Factors/genetics",
author = "Kajari Karmakar and Yuichi Narita and Jonathan Fadok and Sebastien Ducret and Alberto Loche and Taro Kitazawa and Christel Genoud and {Di Meglio}, Thomas and Raphael Thierry and Joao Bacelo and Andreas L{\"u}thi and Rijli, {Filippo M}",
note = "Copyright {\textcopyright} 2017 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = jan,
day = "3",
doi = "10.1016/j.celrep.2016.12.021",
language = "English",
volume = "18",
pages = "185--197",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}