How Viruses Hijack and Modify the Secretory Transport Pathway

Zubaida Hassan; Nilima Dinesh Kumar; Fulvio Reggiori; Gulfaraz Khan

doi:10.3390/cells10102535

How Viruses Hijack and Modify the Secretory Transport Pathway

Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

22 Citationer (Scopus)

Abstract

Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

Originalsprog	Engelsk
Artikelnummer	2535
Tidsskrift	Cells
Vol/bind	10
Nummer	10
DOI	https://doi.org/10.3390/cells10102535
Status	Udgivet - okt. 2021
Udgivet eksternt	Ja

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abstract = "Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.",

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author = "Zubaida Hassan and Kumar, {Nilima Dinesh} and Fulvio Reggiori and Gulfaraz Khan",

year = "2021",

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AU - Hassan, Zubaida

AU - Kumar, Nilima Dinesh

AU - Reggiori, Fulvio

AU - Khan, Gulfaraz

PY - 2021/10

Y1 - 2021/10

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AB - Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

KW - Biological Transport/physiology

KW - Cell Membrane/metabolism

KW - Endoplasmic Reticulum/metabolism

KW - Golgi Apparatus/metabolism

KW - Humans

KW - Secretory Pathway/physiology

KW - Viruses/isolation & purification

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U2 - 10.3390/cells10102535

DO - 10.3390/cells10102535

M3 - Review

C2 - 34685515

VL - 10

JO - Cells

JF - Cells

IS - 10

M1 - 2535

ER -

How Viruses Hijack and Modify the Secretory Transport Pathway

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