How time to healthy singleton delivery could affect decision-making during infertility treatment: a Delphi consensus

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Dokumenter

DOI

  • Ernesto Bosch, Instituto Valenciano de Infertilidad
  • ,
  • Carlo Bulletti, Extra Omnes Medicina e Salute Riproduttiva
  • ,
  • Alan B. Copperman, Icahn School of Medicine at Mount Sinai
  • ,
  • Renato Fanchin, University Paris-Ouest
  • ,
  • Hakan Yarali, Hacettepe University School of Medicine, Anatolia IVF and Women's Health Centre
  • ,
  • Carlos A. Petta, Campinas and Hospital Sirio Libanês
  • ,
  • Nikolaos P. Polyzos, Vrije Universiteit Brussel, Dexeus University Hospital
  • ,
  • Daniel Shapiro, Reproductive Biology Associates
  • ,
  • Filippo Maria Ubaldi, G.EN.E.R.A. Centres for Reproductive Medicine
  • ,
  • Juan A. Garcia Velasco, Dept. de Ciencias de la Salud II, Universidad Rey Juan Carlos, Alcorcón, Madrid
  • ,
  • Salvatore Longobardi, Merck KGaA
  • ,
  • Thomas D'Hooghe, Instituut voor Kern- en Stralingsfysica
  • ,
  • Peter Humaidan
  • Delphi TTP Consensus Group

Research question: How might time to healthy singleton delivery affect decision-making during infertility treatment? Design: This was a Delphi consensus investigating expert opinion that comprised three steps. In Step 1, 12 experts developed statements. In Step 2, 27 experts (including 12 from Step 1) voted (online survey) on their agreement/disagreement with each statement (providing reasons). Consensus was reached if ≥66% of participants agreed/disagreed. Statements not reaching consensus were revised and the process repeated until consensus was achieved. In Step 3 details of the final agreed statements were communicated. Results: Twelve statements were developed, and consensus (agreement) was reached on all after one round of voting. Conclusions: Time to healthy singleton delivery should be taken into consideration when making decisions related to infertility treatment, and it is important that fertility treatment is provided in a timely manner, avoiding over- or under-treatment. In all subfertile women <40 years old, IVF outcomes could be optimized by performing up to six single-embryo transfers and certain procedures might reduce time to healthy singleton delivery. These procedures include preimplantation genetic testing for aneuploidies, frozen replacement cycles immediately after failed fresh cycles and use of gonadotrophin-releasing hormone antagonists. Finally, the number of oocytes retrieved should be maximized to increase cumulative live birth rate.

OriginalsprogEngelsk
TidsskriftReproductive BioMedicine Online
Vol/bind38
Nummer1
Sider (fra-til)118-130
Antal sider13
ISSN1472-6483
DOI
StatusUdgivet - 2019

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