Host genetics and the rumen microbiome jointly associate with methane emissions in dairy cows

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  • Gareth Frank Difford, Animal Breeding and Genomics, Wageningen University & Research, 6700AH, Wageningen, The Netherlands.
  • ,
  • Damian Rafal Plichta, Clinical-Microbiomics A/S, Copenhagen, Denmark.
  • ,
  • Peter Løvendahl
  • Jan Lassen
  • Samantha Joan Noel
  • Ole Højberg
  • André-Denis G Wright, School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States of America.
  • ,
  • Zhigang Zhu
  • ,
  • Lise Kristensen
  • ,
  • Henrik Bjørn Nielsen, Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark., Clinical-Microbiomics A/S, Copenhagen, Denmark.
  • ,
  • Bernt Guldbrandtsen
  • Goutam Sahana

Cattle and other ruminants produce large quantities of methane (~110 million metric tonnes per annum), which is a potent greenhouse gas affecting global climate change. Methane (CH4) is a natural by-product of gastro-enteric microbial fermentation of feedstuffs in the rumen and contributes to 6% of total CH4 emissions from anthropogenic-related sources. The extent to which the host genome and rumen microbiome influence CH4 emission is not yet well known. This study confirms individual variation in CH4 production was influenced by individual host (cow) genotype, as well as the host's rumen microbiome composition. Abundance of a small proportion of bacteria and archaea taxa were influenced to a limited extent by the host's genotype and certain taxa were associated with CH4 emissions. However, the cumulative effect of all bacteria and archaea on CH4 production was 13%, the host genetics (heritability) was 21% and the two are largely independent. This study demonstrates variation in CH4 emission is likely not modulated through cow genetic effects on the rumen microbiome. Therefore, the rumen microbiome and cow genome could be targeted independently, by breeding low methane-emitting cows and in parallel, by investigating possible strategies that target changes in the rumen microbiome to reduce CH4 emissions in the cattle industry.

OriginalsprogEngelsk
TidsskriftPLOS Genetics
Vol/bind14
Nummer10
Sider (fra-til)e1007580
Antal sider22
ISSN1553-7390
DOI
StatusUdgivet - 12 okt. 2018

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