HLA variation and disease

TY - JOUR

T1 - HLA variation and disease

AU - Dendrou, Calliope A

AU - Petersen, Jan

AU - Rossjohn, Jamie

AU - Fugger, Lars

PY - 2018/5

Y1 - 2018/5

N2 - Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.

AB - Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.

U2 - 10.1038/nri.2017.143

DO - 10.1038/nri.2017.143

M3 - Review

C2 - 29292391

SN - 1474-1733

VL - 18

SP - 325

EP - 339

JO - Nature Reviews. Immunology

JF - Nature Reviews. Immunology

IS - 5

ER -