High-sensitivity troponin T and I in patients suspected of acute myocardial infarction

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Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigation. Such data may guide clinicians treating patients suspected of MI. Plasma concentrations of cTnT and cTnI were measured in 503 consecutive patients at Aarhus University Hospital between June 13th and June 27th, 2019. cTnT was measured with the Roche cobas® E602 hs-cTnT assay, while cTnI was measured with the Siemens ADVIA Centaur® XPT hs-cTnI assay. Analytical agreement was determined based on assay-specific 99th percentiles. Medical records were reviewed for adjudication of the MI diagnosis. MI was the final diagnosis in 65 patients (12.9%) and the analytical agreement between cTnT and cTnI assays was 95.2%. For patients diagnosed with MI, cTnI reached higher peak concentrations in shorter time, compared to cTnT. All-cause mortality risk increased with increasing levels of both biomarkers. In this study, the analytical agreement of two cTn assays was high. However, some disparities in troponin trajectories were observed.

OriginalsprogEngelsk
BogserieScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind82
Nummer2
Sider (fra-til)96-103
Antal sider8
ISSN0036-5513
DOI
StatusUdgivet - apr. 2022

Bibliografisk note

Funding Information:
The study was funded by Aarhus University Hospital and partly funded by Siemens Healthineers.

Publisher Copyright:
© 2022 Medisinsk Fysiologisk Forenings Forlag (MFFF).

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