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Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases

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Background and Aims: There is an unmet need for new bi-omarkers to improve diagnostics and prognostics in primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Inter-alpha-inhibitor heavy chain 4 (ITIH4) is an abun-dant, liver-produced protein, and its synthesis may be al-tered in liver diseases. We investigated whether ITIH4 plas-ma concentrations were affected in PBC and PSC patients. Methods: We developed an immunoassay specific for ITIH4 and determined ITIH4 plasma concentrations in 66 PBC, 126 PSC, 92 autoimmune hepatitis (AIH), 67 chronic hepatitis C (CHC), 33 alcoholic hepatitis (AH) patients and 138 healthy controls (HCs). Hepatic ITIH4 expression was investigated by immunohistochemistry in PBC. Results: The mean plas-ma concentration of ITIH4 was almost doubled in PBC [409 mu g/mL (95% CI: 388-431)] and 35% higher in PSC [308 mu g/mL, (95% CI: 296-319)] compared with HCs [226 mu g/ mL (95% CI: 221-231); p

TidsskriftJournal of clinical and translational hepatology
Sider (fra-til)796–802
Antal sider7
StatusUdgivet - okt. 2022

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