Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course

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Abstract

Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative effects, but IL-22 has not been studied during the course of AH. IL-22 is mainly produced by CD4(+) (helper) T cells, including Th17 cells. In addition, Th17 cells produce the proinflammatory cytokine IL-17A, which has been implicated in AH.
OriginalsprogEngelsk
TidsskriftPLOS ONE
Vol/bind8
Nummer1
Sider (fra-til)e55101
ISSN1932-6203
DOI
StatusUdgivet - 2013

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