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High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results

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High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. / Østergaard, Leif; Sorensen, A G; Kwong, K K; Weisskoff, R M; Gyldensted, C; Rosen, B R.

I: Magnetic Resonance in Medicine, Bind 36, Nr. 5, 1996, s. 726-36.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Østergaard, L, Sorensen, AG, Kwong, KK, Weisskoff, RM, Gyldensted, C & Rosen, BR 1996, 'High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results', Magnetic Resonance in Medicine, bind 36, nr. 5, s. 726-36. https://doi.org/10.1002/mrm.1910360511

APA

Østergaard, L., Sorensen, A. G., Kwong, K. K., Weisskoff, R. M., Gyldensted, C., & Rosen, B. R. (1996). High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. Magnetic Resonance in Medicine, 36(5), 726-36. https://doi.org/10.1002/mrm.1910360511

CBE

MLA

Vancouver

Author

Østergaard, Leif ; Sorensen, A G ; Kwong, K K ; Weisskoff, R M ; Gyldensted, C ; Rosen, B R. / High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. I: Magnetic Resonance in Medicine. 1996 ; Bind 36, Nr. 5. s. 726-36.

Bibtex

@article{84281240fb3511dd8f9a000ea68e967b,
title = "High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results",
abstract = "This report evaluates several methods to map relative cerebral blood flow (rCBF) by applying both parametric and nonparametric techniques to deconvolve high resolution dynamic MRI measurements of paramagnetic bolus passages with noninvasively determined arterial inputs. We found a nonparametric (singular value decomposition (SVD)) deconvolution technique produced the most robust results, giving mean gray:white flow ratio of 2.7 +/- 0.5 (SEM) in six normal volunteers, in excellent agreement with recent PET literature values for age-matched subjects. Similar results were obtained by using a model-dependent approach that assumes an exponential residue function, but not for a Gaussian-shaped residue function or for either Fourier or regularization-based model-independent approaches. Pilot studies of our CBF mapping techniques in patients with tumor, stroke, and migraine aura demonstrated that these techniques can be readily used on data routinely acquired by using current echo planar imaging technology. By using these techniques, the authors visualized important regional hemodynamic changes not detectable with rCBV mapping algorithms.",
keywords = "Adult, Brain Neoplasms, Cerebrovascular Circulation, Cerebrovascular Disorders, Humans, Magnetic Resonance Imaging, Middle Aged, Migraine Disorders, Models, Theoretical, Monte Carlo Method",
author = "Leif {\O}stergaard and Sorensen, {A G} and Kwong, {K K} and Weisskoff, {R M} and C Gyldensted and Rosen, {B R}",
year = "1996",
doi = "10.1002/mrm.1910360511",
language = "English",
volume = "36",
pages = "726--36",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results

AU - Østergaard, Leif

AU - Sorensen, A G

AU - Kwong, K K

AU - Weisskoff, R M

AU - Gyldensted, C

AU - Rosen, B R

PY - 1996

Y1 - 1996

N2 - This report evaluates several methods to map relative cerebral blood flow (rCBF) by applying both parametric and nonparametric techniques to deconvolve high resolution dynamic MRI measurements of paramagnetic bolus passages with noninvasively determined arterial inputs. We found a nonparametric (singular value decomposition (SVD)) deconvolution technique produced the most robust results, giving mean gray:white flow ratio of 2.7 +/- 0.5 (SEM) in six normal volunteers, in excellent agreement with recent PET literature values for age-matched subjects. Similar results were obtained by using a model-dependent approach that assumes an exponential residue function, but not for a Gaussian-shaped residue function or for either Fourier or regularization-based model-independent approaches. Pilot studies of our CBF mapping techniques in patients with tumor, stroke, and migraine aura demonstrated that these techniques can be readily used on data routinely acquired by using current echo planar imaging technology. By using these techniques, the authors visualized important regional hemodynamic changes not detectable with rCBV mapping algorithms.

AB - This report evaluates several methods to map relative cerebral blood flow (rCBF) by applying both parametric and nonparametric techniques to deconvolve high resolution dynamic MRI measurements of paramagnetic bolus passages with noninvasively determined arterial inputs. We found a nonparametric (singular value decomposition (SVD)) deconvolution technique produced the most robust results, giving mean gray:white flow ratio of 2.7 +/- 0.5 (SEM) in six normal volunteers, in excellent agreement with recent PET literature values for age-matched subjects. Similar results were obtained by using a model-dependent approach that assumes an exponential residue function, but not for a Gaussian-shaped residue function or for either Fourier or regularization-based model-independent approaches. Pilot studies of our CBF mapping techniques in patients with tumor, stroke, and migraine aura demonstrated that these techniques can be readily used on data routinely acquired by using current echo planar imaging technology. By using these techniques, the authors visualized important regional hemodynamic changes not detectable with rCBV mapping algorithms.

KW - Adult

KW - Brain Neoplasms

KW - Cerebrovascular Circulation

KW - Cerebrovascular Disorders

KW - Humans

KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Migraine Disorders

KW - Models, Theoretical

KW - Monte Carlo Method

U2 - 10.1002/mrm.1910360511

DO - 10.1002/mrm.1910360511

M3 - Journal article

C2 - 8916023

VL - 36

SP - 726

EP - 736

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 5

ER -