Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss

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  • Camilo Miguel Signorelli, University of Oxford, Universite Paris-Sud, Pompeu Fabra University
  • ,
  • Lynn Uhrig, University Paris Descartes, Paris, Institut National de la Santé et de la Recherche Médicale
  • ,
  • Morten Kringelbach
  • Bechir Jarraya, Universite Paris-Saclay, Hopital Foch, Institut National de la Santé et de la Recherche Médicale
  • ,
  • Gustavo Deco, Pompeu Fabra University, Institució Catalana de la Recerca i Estudis Avançats, Max Planck Institute for Human Cognitive and Brain Sciences, Monash University

Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness. Here we suggest that the mechanism of conscious access is related to a general dynamical rearrangement of the intrinsic hierarchical organization of the cortex. To measure cortical hierarchy, we applied the Intrinsic Ignition analysis to resting-state fMRI data acquired in awake and anesthetized macaques. Our results reveal the existence of spatial and temporal hierarchical differences of neural activity within the macaque cortex, with a strong modulation by the depth of anesthesia and the employed anesthetic agent. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics whereas lower values correspond to poor and rigid, structurally driven brain dynamics. Moreover, spatial and temporal hierarchical dimensions are disrupted in a different manner, involving different hierarchical brain networks. All together suggest that disruption of brain hierarchy is a new signature of consciousness loss.

OriginalsprogEngelsk
Artikelnummer117618
TidsskriftNeuroImage
Vol/bind227
ISSN1053-8119
DOI
StatusUdgivet - feb. 2021

Bibliografisk note

Funding Information:
The authors thank Jordy Tasserie for help with data transfer; Morgan Dupont and Wilfried Pianezzola for help with animal experiments; Alexis Amadon, Hauke Kolster, Laurent Laribière, Jérémy Bernard, Eric Giacomini, Michel Luong, Edouard Chazel, and the NeuroSpin magnetic resonance imaging and informatics teams for help with imaging tools; Sébastien Mériaux and Joël Cotton for animal facilities; and Jean-Robert Deverre, for administrative support, Commissariat à l'Énergie atomique et aux Énergies alternatives (CEA /Joliot). The authors also thank the anonymous reviewers for your relevant remarks and positive consideration. The first author also appreciate the support from Comisión Nacional de Investigación Ciencia y Tecnología (CONICYT, currently ANID) through Programa Formacion de Capital Avanzado (PFCHA), Doctoral scholarship Becas Chile: CONICYT PFCHA/DOCTORADO BECAS CHILE/2016 - 72170507.

Publisher Copyright:
© 2020

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

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