Hebbian plasticity in vivo: relevance and induction

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Hebbian plasticity in vivo : relevance and induction. / Andersen, Niels; Krauth, Nathalie; Nabavi, Sadegh.

I: Current Opinion in Neurobiology, Bind 45, 01.08.2017, s. 188-192.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Andersen, Niels ; Krauth, Nathalie ; Nabavi, Sadegh. / Hebbian plasticity in vivo : relevance and induction. I: Current Opinion in Neurobiology. 2017 ; Bind 45. s. 188-192.

Bibtex

@article{8367ab65d97d443598ea876cfcb022ec,
title = "Hebbian plasticity in vivo: relevance and induction",
abstract = "Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.",
author = "Niels Andersen and Nathalie Krauth and Sadegh Nabavi",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.conb.2017.06.001",
language = "English",
volume = "45",
pages = "188--192",
journal = "Current Opinion in Neurobiology",
issn = "0959-4388",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Hebbian plasticity in vivo

T2 - relevance and induction

AU - Andersen, Niels

AU - Krauth, Nathalie

AU - Nabavi, Sadegh

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.

AB - Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.

UR - http://www.scopus.com/inward/record.url?scp=85021668316&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2017.06.001

DO - 10.1016/j.conb.2017.06.001

M3 - Review

VL - 45

SP - 188

EP - 192

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

ER -