Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study

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  • Mari C.W. Myhrstad, Høgskolen i Oslo og Akershus
  • ,
  • Vanessa D. de Mello, University of Eastern Finland
  • ,
  • Ingrid Dahlman, Karolinska Institutet
  • ,
  • Marjukka Kolehmainen, University of Eastern Finland
  • ,
  • Jussi Paananen, University of Eastern Finland
  • ,
  • Amanda Rundblad, Universitetet i Oslo
  • ,
  • Carsten Carlberg, University of Eastern Finland
  • ,
  • Ole Kristoffer Olstad, University of Oslo, Oslo University Hospital, Oslo
  • ,
  • Jussi Pihlajamäki, University of Eastern Finland, Division of Cardiology, Kuopio University Central Hospital
  • ,
  • Kirsten B. Holven, Universitetet i Oslo, University of Oslo, Oslo University Hospital, Oslo
  • ,
  • Kjeld Hermansen
  • Lars O. Dragsted, Københavns Universitet
  • ,
  • Ingibjörg Gunnarsdottir, Landspitali National University Hospital of Iceland
  • ,
  • Lieselotte Cloetens, Lunds Universitet
  • ,
  • Matilda Ulmius Storm, Lunds Universitet
  • ,
  • Björn Åkesson, Lunds Universitet, Lund University Hospital
  • ,
  • Fredrik Rosqvist, Uppsala universitet
  • ,
  • Janne Hukkanen, Oulun Yliopisto
  • ,
  • Karl Heinz Herzig, Oulun Yliopisto, Poznan University of Medical Sciences
  • ,
  • Ulf Risérus, Uppsala universitet
  • ,
  • Inga Thorsdottir, Landspitali National University Hospital of Iceland
  • ,
  • Kaisa S. Poutanen, University of Eastern Finland, Technical Research Centre of Finland (VTT)
  • ,
  • Markku J. Savolainen, Oulun Yliopisto
  • ,
  • Ursula Schwab, University of Eastern Finland, Division of Cardiology, Kuopio University Central Hospital
  • ,
  • Peter Arner, Karolinska Institutet
  • ,
  • Matti Uusitupa, University of Eastern Finland
  • ,
  • Stine M. Ulven, Universitetet i Oslo

Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results: Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-κB, are downregulated in the healthy Nordic diet group. Conclusion: These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

OriginalsprogEngelsk
Artikelnummer1801405
TidsskriftMolecular Nutrition and Food Research
Vol/bind63
Nummer13
Antal sider13
ISSN1613-4125
DOI
StatusUdgivet - 2019

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