Healthy ageing - from molecules to hormesis

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Ageing can be understood at various levels, from evolutionary and biological levels to psychological and sociological levels. At the molecular biological level ageing is characterized by the stochastic occurrence and progressive accumulation of molecular damage. Failure of homeodynamics, increased molecular heterogeneity, altered cellular functioning and reduced stress tolerance are the determinants of health status, probability of diseases and the duration of survival. The inefficiency and imperfection of the maintenance and repair systems underlie the biological basis of ageing. Two major issues yet to be resolved in bigerontology are determining the physiological relevance of various types of molecular damage, and establishing the nature of healthy and unhealthy gene-protein networks. Gene therapy, stem cells, and modulation through functional foods, nutriceuticals, cosmeceuticals and other life style alterations are examples of ageing interventions. A promising healthy-ageing approach is that of hormesis by strengthening the homeodynamic ability of self-maintenance through transient and repetitive mild stress-inducing hormetins. Achieving the goal of extended health-span will depend on elucidating and exploiting successful and dynamic interactions among biological, psycho-social and environmental factors.
OriginalsprogEngelsk
TidsskriftNew Biotechnology
Vol/bind29
Nummersupplement
Sider (fra-til)S20
Antal sider1
ISSN1871-6784
DOI
StatusUdgivet - 23 sep. 2012
Begivenhed15th European Congress on Biotechnology - Istanbul, Tyrkiet
Varighed: 23 sep. 201226 sep. 2012

Konference

Konference15th European Congress on Biotechnology
LandTyrkiet
ByIstanbul
Periode23/09/201226/09/2012

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