Health-Related Quality of Life during 26-Week Intervention with the New Nordic Renal Diet

Nikita Misella Hansen; Anne-Lise Kamper; Marianne Rix; Bo Feldt-Rasmussen; Peder Berg; Arne Astrup; Louise Salomo

doi:10.3390/nu16132038

Health-Related Quality of Life during 26-Week Intervention with the New Nordic Renal Diet

Nikita Misella Hansen, Anne-Lise Kamper, Marianne Rix, Bo Feldt-Rasmussen, Peder Berg, Arne Astrup, Louise Salomo

Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

The New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b–4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL). Sixty participants were recruited (NNRD group n = 30, control group n = 30) and 58 completed the study. During the intervention, the NNRD group received food boxes, and recipes once a week. The control group continued their habitual diet. HRQoL was examined at baseline and at the end of the intervention using the validated EuroQol-5D-5L, including a 5-point scale Likert questionnaire at the end of the intervention. Assessed by the EuroQol-5D-5L questionnaire, the NNRD group experienced a reduction in pain/discomfort during the intervention by 26% [−0.44 points (95% CI; −0.73, −0.16)], compared with no change in the control group [0.25 points (95% CI; −0.02, 0.53)] and a between-group difference of −0.70 points (95% CI; −1.03, −0.37, p < 0.001). A larger decrease of body fat mass was associated with a larger decrease in pain/discomfort (p = 0.014). In addition, the NNRD group reported an overall improvement in conducting usual daily activities by 23% [−0.30-point (95% CI; −0.50, −0.11)], while no change was seen in the control group [−0.02 points (95% CI; −0.21, 0.17)], with a between-group difference −0.28 points (95% CI; −0.51, −0.06, p = 0.014). A larger decrease in 24 h urine phosphorus excretion, used as a marker of compliance, was associated with a larger improvement in conducting usual daily activities (p = 0.036). The NNRD group had a clinically relevant improvement in various HRQoL outcomes.

Originalsprog	Engelsk
Artikelnummer	2038
Tidsskrift	Nutrients
Vol/bind	16
Nummer	13
Antal sider	12
ISSN	2072-6643
DOI	https://doi.org/10.3390/nu16132038
Status	Udgivet - jul. 2024

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10.3390/nu16132038Licens: CC BY

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title = "Health-Related Quality of Life during 26-Week Intervention with the New Nordic Renal Diet",

abstract = "The New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b–4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL). Sixty participants were recruited (NNRD group n = 30, control group n = 30) and 58 completed the study. During the intervention, the NNRD group received food boxes, and recipes once a week. The control group continued their habitual diet. HRQoL was examined at baseline and at the end of the intervention using the validated EuroQol-5D-5L, including a 5-point scale Likert questionnaire at the end of the intervention. Assessed by the EuroQol-5D-5L questionnaire, the NNRD group experienced a reduction in pain/discomfort during the intervention by 26% [−0.44 points (95% CI; −0.73, −0.16)], compared with no change in the control group [0.25 points (95% CI; −0.02, 0.53)] and a between-group difference of −0.70 points (95% CI; −1.03, −0.37, p < 0.001). A larger decrease of body fat mass was associated with a larger decrease in pain/discomfort (p = 0.014). In addition, the NNRD group reported an overall improvement in conducting usual daily activities by 23% [−0.30-point (95% CI; −0.50, −0.11)], while no change was seen in the control group [−0.02 points (95% CI; −0.21, 0.17)], with a between-group difference −0.28 points (95% CI; −0.51, −0.06, p = 0.014). A larger decrease in 24 h urine phosphorus excretion, used as a marker of compliance, was associated with a larger improvement in conducting usual daily activities (p = 0.036). The NNRD group had a clinically relevant improvement in various HRQoL outcomes.",

keywords = "EQ-5D-5L, Likert scale, chronic kidney disease, dietary intervention, food delivery, health-related quality of life, phosphorus, randomized clinical trial",

author = "Hansen, {Nikita Misella} and Anne-Lise Kamper and Marianne Rix and Bo Feldt-Rasmussen and Peder Berg and Arne Astrup and Louise Salomo",

year = "2024",

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AU - Hansen, Nikita Misella

AU - Kamper, Anne-Lise

AU - Rix, Marianne

AU - Feldt-Rasmussen, Bo

AU - Berg, Peder

AU - Astrup, Arne

AU - Salomo, Louise

PY - 2024/7

Y1 - 2024/7

N2 - The New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b–4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL). Sixty participants were recruited (NNRD group n = 30, control group n = 30) and 58 completed the study. During the intervention, the NNRD group received food boxes, and recipes once a week. The control group continued their habitual diet. HRQoL was examined at baseline and at the end of the intervention using the validated EuroQol-5D-5L, including a 5-point scale Likert questionnaire at the end of the intervention. Assessed by the EuroQol-5D-5L questionnaire, the NNRD group experienced a reduction in pain/discomfort during the intervention by 26% [−0.44 points (95% CI; −0.73, −0.16)], compared with no change in the control group [0.25 points (95% CI; −0.02, 0.53)] and a between-group difference of −0.70 points (95% CI; −1.03, −0.37, p < 0.001). A larger decrease of body fat mass was associated with a larger decrease in pain/discomfort (p = 0.014). In addition, the NNRD group reported an overall improvement in conducting usual daily activities by 23% [−0.30-point (95% CI; −0.50, −0.11)], while no change was seen in the control group [−0.02 points (95% CI; −0.21, 0.17)], with a between-group difference −0.28 points (95% CI; −0.51, −0.06, p = 0.014). A larger decrease in 24 h urine phosphorus excretion, used as a marker of compliance, was associated with a larger improvement in conducting usual daily activities (p = 0.036). The NNRD group had a clinically relevant improvement in various HRQoL outcomes.

AB - The New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b–4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL). Sixty participants were recruited (NNRD group n = 30, control group n = 30) and 58 completed the study. During the intervention, the NNRD group received food boxes, and recipes once a week. The control group continued their habitual diet. HRQoL was examined at baseline and at the end of the intervention using the validated EuroQol-5D-5L, including a 5-point scale Likert questionnaire at the end of the intervention. Assessed by the EuroQol-5D-5L questionnaire, the NNRD group experienced a reduction in pain/discomfort during the intervention by 26% [−0.44 points (95% CI; −0.73, −0.16)], compared with no change in the control group [0.25 points (95% CI; −0.02, 0.53)] and a between-group difference of −0.70 points (95% CI; −1.03, −0.37, p < 0.001). A larger decrease of body fat mass was associated with a larger decrease in pain/discomfort (p = 0.014). In addition, the NNRD group reported an overall improvement in conducting usual daily activities by 23% [−0.30-point (95% CI; −0.50, −0.11)], while no change was seen in the control group [−0.02 points (95% CI; −0.21, 0.17)], with a between-group difference −0.28 points (95% CI; −0.51, −0.06, p = 0.014). A larger decrease in 24 h urine phosphorus excretion, used as a marker of compliance, was associated with a larger improvement in conducting usual daily activities (p = 0.036). The NNRD group had a clinically relevant improvement in various HRQoL outcomes.

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KW - Likert scale

KW - chronic kidney disease

KW - dietary intervention

KW - food delivery

KW - health-related quality of life

KW - phosphorus

KW - randomized clinical trial

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U2 - 10.3390/nu16132038

DO - 10.3390/nu16132038

M3 - Journal article

C2 - 38999786

SN - 2072-6643

VL - 16

JO - Nutrients

JF - Nutrients

IS - 13

M1 - 2038

ER -

Health-Related Quality of Life during 26-Week Intervention with the New Nordic Renal Diet

Abstract

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