Head circumference at birth and school performance: a nationwide cohort study of 536,921 children

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Head circumference at birth and school performance : a nationwide cohort study of 536,921 children. / Bach, Cathrine C; Henriksen, Tine B; Larsen, René T; Aagaard, Kristina; Matthiesen, Niels B.

I: Pediatric Research, Bind 87, 05.2020, s. 1112-1118.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{53ccd5b0ae6b43ea9a696d0117870e55,
title = "Head circumference at birth and school performance: a nationwide cohort study of 536,921 children",
abstract = "BACKGROUND: Early measures of cognitive function are of great public health interest. We aimed to estimate the association between head circumference at birth, a measure of cerebral size, and school performance.METHODS: We conducted a nationwide cohort study of all liveborn singletons in Denmark, 1997-2005. The association between birth head circumference z score and test scores in reading and mathematics from a nationwide mandatory computer-based school test program (7-16 years) was estimated by multivariable linear regression adjusted for potential confounders.RESULTS: The cohort included 536,921 children. Compared to normocephalic children, children with microcephaly [<-2 standard deviations (SD)] had lower mean reading scores: second grade: -0.08 SD (95% CI -0.10 to -0.06), eighth grade: -0.07 SD (95% CI -0.10 to -0.04). Macrocephaly (>+2 SD) was associated with higher scores. In normocephalic children, each SD increase in head circumference was associated with a 0.03 SD (95% CI 0.03 to 0.04) increase in mean reading scores. The results were similar across grades within both reading and mathematics.CONCLUSION: Prenatal brain growth may be causally related to childhood school performance. The demonstrated differences are unlikely to be clinically relevant at the individual level but may be important at a public health level.",
author = "Bach, {Cathrine C} and Henriksen, {Tine B} and Larsen, {Ren{\'e} T} and Kristina Aagaard and Matthiesen, {Niels B}",
year = "2020",
month = may,
doi = "10.1038/s41390-019-0683-2",
language = "English",
volume = "87",
pages = "1112--1118",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Head circumference at birth and school performance

T2 - a nationwide cohort study of 536,921 children

AU - Bach, Cathrine C

AU - Henriksen, Tine B

AU - Larsen, René T

AU - Aagaard, Kristina

AU - Matthiesen, Niels B

PY - 2020/5

Y1 - 2020/5

N2 - BACKGROUND: Early measures of cognitive function are of great public health interest. We aimed to estimate the association between head circumference at birth, a measure of cerebral size, and school performance.METHODS: We conducted a nationwide cohort study of all liveborn singletons in Denmark, 1997-2005. The association between birth head circumference z score and test scores in reading and mathematics from a nationwide mandatory computer-based school test program (7-16 years) was estimated by multivariable linear regression adjusted for potential confounders.RESULTS: The cohort included 536,921 children. Compared to normocephalic children, children with microcephaly [<-2 standard deviations (SD)] had lower mean reading scores: second grade: -0.08 SD (95% CI -0.10 to -0.06), eighth grade: -0.07 SD (95% CI -0.10 to -0.04). Macrocephaly (>+2 SD) was associated with higher scores. In normocephalic children, each SD increase in head circumference was associated with a 0.03 SD (95% CI 0.03 to 0.04) increase in mean reading scores. The results were similar across grades within both reading and mathematics.CONCLUSION: Prenatal brain growth may be causally related to childhood school performance. The demonstrated differences are unlikely to be clinically relevant at the individual level but may be important at a public health level.

AB - BACKGROUND: Early measures of cognitive function are of great public health interest. We aimed to estimate the association between head circumference at birth, a measure of cerebral size, and school performance.METHODS: We conducted a nationwide cohort study of all liveborn singletons in Denmark, 1997-2005. The association between birth head circumference z score and test scores in reading and mathematics from a nationwide mandatory computer-based school test program (7-16 years) was estimated by multivariable linear regression adjusted for potential confounders.RESULTS: The cohort included 536,921 children. Compared to normocephalic children, children with microcephaly [<-2 standard deviations (SD)] had lower mean reading scores: second grade: -0.08 SD (95% CI -0.10 to -0.06), eighth grade: -0.07 SD (95% CI -0.10 to -0.04). Macrocephaly (>+2 SD) was associated with higher scores. In normocephalic children, each SD increase in head circumference was associated with a 0.03 SD (95% CI 0.03 to 0.04) increase in mean reading scores. The results were similar across grades within both reading and mathematics.CONCLUSION: Prenatal brain growth may be causally related to childhood school performance. The demonstrated differences are unlikely to be clinically relevant at the individual level but may be important at a public health level.

U2 - 10.1038/s41390-019-0683-2

DO - 10.1038/s41390-019-0683-2

M3 - Journal article

C2 - 31779026

VL - 87

SP - 1112

EP - 1118

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

ER -