Head circumference at birth and intellectual disability: a nationwide cohort study

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Head circumference at birth and intellectual disability : a nationwide cohort study. / Aagaard, Kristina; Matthiesen, Niels B; Bach, Cathrine C; Larsen, René T; Henriksen, Tine B.

I: Pediatric Research, Bind 87, Nr. 3, 02.2020, s. 595-601.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{3acd70b808314d5b850cff2f3fa92d23,
title = "Head circumference at birth and intellectual disability: a nationwide cohort study",
abstract = "BACKGROUND: Intellectual disability (ID) is a prevalent chronic disability affecting up to 1-3% of the general population. Small head circumference at birth, a surrogate measure of foetal cerebral growth, may be a risk factor for ID. We aimed to investigate the association between the full distribution of head circumference at birth and ID.METHODS: This cohort study was based on Danish nationwide registries and included all Danish singletons born alive from 1997 to 2013. Follow-up ended at October 2015. The data was analysed using a Cox proportional hazards regression model adjusted for a large number of potential confounders.RESULTS: The cohort comprised 986,909 infants. Neither microcephaly nor macrocephaly at birth was consistently associated with the risk of ID. Within the normal range of head circumference, larger head circumference was associated with a decreased risk of ID (HR per standard deviation increase in head circumference z score 0.85, 95% CI 0.81-0.88). The association detected within the normal range was consistent in all sensitivity analyses.CONCLUSIONS: Intrauterine brain growth restriction may be a risk factor for ID.",
keywords = "ADOLESCENTS, ASSOCIATIONS, CHILDREN, DEFECTS, DISORDER, GESTATIONAL-AGE, GROWTH, PERFORMANCE, PREGNANCY, RISK",
author = "Kristina Aagaard and Matthiesen, {Niels B} and Bach, {Cathrine C} and Larsen, {Ren{\'e} T} and Henriksen, {Tine B}",
year = "2020",
month = feb,
doi = "10.1038/s41390-019-0593-3",
language = "English",
volume = "87",
pages = "595--601",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - Head circumference at birth and intellectual disability

T2 - a nationwide cohort study

AU - Aagaard, Kristina

AU - Matthiesen, Niels B

AU - Bach, Cathrine C

AU - Larsen, René T

AU - Henriksen, Tine B

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND: Intellectual disability (ID) is a prevalent chronic disability affecting up to 1-3% of the general population. Small head circumference at birth, a surrogate measure of foetal cerebral growth, may be a risk factor for ID. We aimed to investigate the association between the full distribution of head circumference at birth and ID.METHODS: This cohort study was based on Danish nationwide registries and included all Danish singletons born alive from 1997 to 2013. Follow-up ended at October 2015. The data was analysed using a Cox proportional hazards regression model adjusted for a large number of potential confounders.RESULTS: The cohort comprised 986,909 infants. Neither microcephaly nor macrocephaly at birth was consistently associated with the risk of ID. Within the normal range of head circumference, larger head circumference was associated with a decreased risk of ID (HR per standard deviation increase in head circumference z score 0.85, 95% CI 0.81-0.88). The association detected within the normal range was consistent in all sensitivity analyses.CONCLUSIONS: Intrauterine brain growth restriction may be a risk factor for ID.

AB - BACKGROUND: Intellectual disability (ID) is a prevalent chronic disability affecting up to 1-3% of the general population. Small head circumference at birth, a surrogate measure of foetal cerebral growth, may be a risk factor for ID. We aimed to investigate the association between the full distribution of head circumference at birth and ID.METHODS: This cohort study was based on Danish nationwide registries and included all Danish singletons born alive from 1997 to 2013. Follow-up ended at October 2015. The data was analysed using a Cox proportional hazards regression model adjusted for a large number of potential confounders.RESULTS: The cohort comprised 986,909 infants. Neither microcephaly nor macrocephaly at birth was consistently associated with the risk of ID. Within the normal range of head circumference, larger head circumference was associated with a decreased risk of ID (HR per standard deviation increase in head circumference z score 0.85, 95% CI 0.81-0.88). The association detected within the normal range was consistent in all sensitivity analyses.CONCLUSIONS: Intrauterine brain growth restriction may be a risk factor for ID.

KW - ADOLESCENTS

KW - ASSOCIATIONS

KW - CHILDREN

KW - DEFECTS

KW - DISORDER

KW - GESTATIONAL-AGE

KW - GROWTH

KW - PERFORMANCE

KW - PREGNANCY

KW - RISK

U2 - 10.1038/s41390-019-0593-3

DO - 10.1038/s41390-019-0593-3

M3 - Journal article

C2 - 31578043

VL - 87

SP - 595

EP - 601

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 3

ER -