Growth Hormone and Obesity

Astrid Hjelholt; Morten Høgild; Ann Mosegaard Bak; Mai Christiansen Arlien-Søborg; Amanda Bæk; Niels Jessen; Bjørn Richelsen; Steen Bønløkke Pedersen; Niels Møller; Jens Otto Lunde Jørgensen

doi:10.1016/j.ecl.2020.02.009

Growth Hormone and Obesity

Astrid Hjelholt, Morten Høgild, Ann Mosegaard Bak, Mai Christiansen Arlien-Søborg, Amanda Bæk, Niels Jessen, Bjørn Richelsen, Steen Bønløkke Pedersen, Niels Møller, Jens Otto Lunde Jørgensen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

42 Citationer (Scopus)

Abstract

Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin levels. Fasting in lean individuals suppresses hepatic IGF-I production and increases pituitary GH release, but this pattern is less pronounced in obesity. Fasting in obesity is associated with increased sensitivity to the insulin-antagonistic effects of GH. GH treatment in obesity induces a moderate reduction in fat mass and an increase in lean body mass but the therapeutic potential is uncertain.

Originalsprog	Engelsk
Tidsskrift	Endocrinology and Metabolism Clinics of North America
Vol/bind	49
Nummer	2
Sider (fra-til)	239-250
Antal sider	12
ISSN	0889-8529
DOI	https://doi.org/10.1016/j.ecl.2020.02.009
Status	Udgivet - 2020

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Citationsformater

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title = "Growth Hormone and Obesity",

abstract = "Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin levels. Fasting in lean individuals suppresses hepatic IGF-I production and increases pituitary GH release, but this pattern is less pronounced in obesity. Fasting in obesity is associated with increased sensitivity to the insulin-antagonistic effects of GH. GH treatment in obesity induces a moderate reduction in fat mass and an increase in lean body mass but the therapeutic potential is uncertain.",

keywords = "Growth hormone, Insulin-like growth factor I, Obesity",

author = "Astrid Hjelholt and Morten H{\o}gild and Bak, {Ann Mosegaard} and Arlien-S{\o}borg, {Mai Christiansen} and Amanda B{\ae}k and Niels Jessen and Bj{\o}rn Richelsen and Pedersen, {Steen B{\o}nl{\o}kke} and Niels M{\o}ller and {Lunde J{\o}rgensen}, {Jens Otto}",

year = "2020",

doi = "10.1016/j.ecl.2020.02.009",

language = "English",

volume = "49",

pages = "239--250",

journal = "Endocrinology and Metabolism Clinics of North America",

issn = "0889-8529",

publisher = "W.B. Saunders",

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TY - JOUR

T1 - Growth Hormone and Obesity

AU - Hjelholt, Astrid

AU - Høgild, Morten

AU - Bak, Ann Mosegaard

AU - Arlien-Søborg, Mai Christiansen

AU - Bæk, Amanda

AU - Jessen, Niels

AU - Richelsen, Bjørn

AU - Pedersen, Steen Bønløkke

AU - Møller, Niels

AU - Lunde Jørgensen, Jens Otto

PY - 2020

Y1 - 2020

N2 - Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin levels. Fasting in lean individuals suppresses hepatic IGF-I production and increases pituitary GH release, but this pattern is less pronounced in obesity. Fasting in obesity is associated with increased sensitivity to the insulin-antagonistic effects of GH. GH treatment in obesity induces a moderate reduction in fat mass and an increase in lean body mass but the therapeutic potential is uncertain.

AB - Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin levels. Fasting in lean individuals suppresses hepatic IGF-I production and increases pituitary GH release, but this pattern is less pronounced in obesity. Fasting in obesity is associated with increased sensitivity to the insulin-antagonistic effects of GH. GH treatment in obesity induces a moderate reduction in fat mass and an increase in lean body mass but the therapeutic potential is uncertain.

KW - Growth hormone

KW - Insulin-like growth factor I

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85083344829&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2020.02.009

DO - 10.1016/j.ecl.2020.02.009

M3 - Review

C2 - 32418587

AN - SCOPUS:85083344829

SN - 0889-8529

VL - 49

SP - 239

EP - 250

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 2

ER -

Growth Hormone and Obesity

Abstract

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