Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Sabina Sieri, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Claudia Agnoli, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Sara Grioni, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Elisabete Weiderpass, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Amalia Mattiello, Department of Clinical Medicine and Surgery, Division of Gastroenterology, Federico II University Hospital School of Medicine, Naples, Italy., Italien
  • Ivonne Sluijs, Univ Utrecht, Utrecht University, Utrecht University Medical Center, UMC Utrecht, Dept Hematol, Holland
  • Maria Jose Sanchez, Andalusian School of Public Health, Granada, Spain., Consorcio Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Instituto de Investigación Biosanitaria (ibs.GRANADA), Department of Preventive Medicine and Public Health, University of Granada, Granada, Spanien
  • Marianne Uhre Jakobsen, Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Søborg, Denmark.
  • ,
  • Michael Sweeting, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Department of Health Sciences and Department of Genetics, University of Leicester, Storbritannien
  • Yvonne T van der Schouw, Univ Utrecht, Utrecht University, Utrecht University Medical Center, UMC Utrecht, Dept Hematol, Holland
  • Lena Maria Nilsson, Umeå University, Sverige
  • Patrik Wennberg, Umeå University, Sverige
  • Verena A Katzke, CCU Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Tilman Kühn, CCU Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany., Tyskland
  • Kim Overvad
  • Tammy Y N Tong, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Moreno-Iribas Conchi, Navarra Public Health Institute, Spanien
  • José Ramón Quirós, Public Health Directorate, Asturias, Spain., Spanien
  • Juan Manuel García-Torrecillas, Hospital Universitario Torrecárdenas, Almería, Spanien
  • Olatz Mokoroa, Biodonostia Health Research Institute, Spanien
  • Jesús-Humberto Gómez, Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • Anne Tjønneland, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Danmark
  • Emiliy Sonestedt, Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, CRC, hus 60 plan 13 205 02 Malmö, Sweden., Sverige
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, Hellenic Health Foundation, Athens, Greece., 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Elissavet Valanou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Jolanda M A Boer, National Institute for Public Health and the Environment (RIVM), Holland
  • W M Monique Verschuren, National Institute for Public Health and the Environment (RIVM), Holland
  • Marie-Christine Boutron-Ruault, Center for Research in Epidemiology and Population Health, University Paris-South, Faculty of Medicine, University Versailles-St Quentin, National Institute for Health and Medical Research, Université Paris-Saclay, Villejuif, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Guy Fagherazzi, Center for Research in Epidemiology and Population Health, University Paris-South, Faculty of Medicine, University Versailles-St Quentin, National Institute for Health and Medical Research, Université Paris-Saclay, Villejuif, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Anne-Laure Madika, Center for Research in Epidemiology and Population Health, University Paris-South, Faculty of Medicine, University Versailles-St Quentin, National Institute for Health and Medical Research, Université Paris-Saclay, Villejuif, Institut Gustave Roussy, Villejuif, France., Université Lille, CHU Lille, Lille, Frankrig
  • Manuela M Bergmann, German Institute of Human Nutrition Potsdam-Rehbrücke, Tyskland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbrücke, DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Tyskland
  • Pietro Ferrari, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Heinz Freisling, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Hannah Lennon, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Carlotta Sacerdote, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Italien
  • Giovanna Masala, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for cancer research, prevention and clinical network (ISPRO), Florence, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, Civic-M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy. rtumino@tin.it., Italien
  • Elio Riboli, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, Storbritannien
  • Nicholas J Wareham, University of Cambridge, School of Clinical Medicine., Storbritannien
  • John Danesh, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Storbritannien
  • Nita G Forouhi, University of Cambridge, School of Clinical Medicine., Storbritannien
  • Adam S Butterworth, MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Storbritannien
  • Vittorio Krogh, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien

BACKGROUND: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk.

OBJECTIVES: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes.

METHODS: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models.

RESULTS: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) ≥25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI <25 [HR: 1.09 (95% CI: 0.98, 1.22) per 50 g/d) (P-interaction = 0.022). The GL-CHD association did not differ between men [HR: 1.19 (95% CI: 1.08, 1.30) per 50 g/d] and women [HR: 1.22 (95% CI: 1.07, 1.40) per 50 g/d] (test for interaction not significant). GI was associated with CHD risk only in the continuous model [HR: 1.04 (95% CI: 1.00, 1.08) per 5 units/d]. High available carbohydrate was associated with greater CHD risk [HR: 1.11 (95% CI: 1.03, 1.18) per 50 g/d]. High sugar intake was associated with greater CHD risk [HR: 1.09 (95% CI: 1.02, 1.17) per 50 g/d].

CONCLUSIONS: This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.

OriginalsprogEngelsk
Artikelnummernqaa157
TidsskriftThe American Journal of Clinical Nutrition
Vol/bind112
Nummer3
Sider (fra-til)631-643
Antal sider13
ISSN0002-9165
DOI
StatusUdgivet - sep. 2020

Bibliografisk note

Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.

Se relationer på Aarhus Universitet Citationsformater

ID: 191855100