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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. / Cross-Disorder Group of the Psychiatric Genomics Consortium.

I: Cell, Bind 179, Nr. 7, 2019, s. 1469-1482.e11.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Cross-Disorder Group of the Psychiatric Genomics Consortium 2019, 'Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders', Cell, bind 179, nr. 7, s. 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

APA

Cross-Disorder Group of the Psychiatric Genomics Consortium (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

CBE

Cross-Disorder Group of the Psychiatric Genomics Consortium. 2019. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 179(7):1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

MLA

Cross-Disorder Group of the Psychiatric Genomics Consortium. "Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders". Cell. 2019, 179(7). 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

Vancouver

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020

Author

Cross-Disorder Group of the Psychiatric Genomics Consortium. / Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. I: Cell. 2019 ; Bind 179, Nr. 7. s. 1469-1482.e11.

Bibtex

@article{c23f2adad5814edd8a9ce27f1d3557be,
title = "Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders",
abstract = "Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.",
keywords = "GWAS, Psychiatric genetics, cross-disorder genetics, functional genomics, gene expression, genetic architecture, genetic correlation, neurodevelopment, pleiotropy, psychiatric disorders",
author = "{Cross-Disorder Group of the Psychiatric Genomics Consortium} and Per Qvist and S{\o}ren Dalsgaard and Christensen, {Jane Hvarregaard}",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
doi = "10.1016/j.cell.2019.11.020",
language = "English",
volume = "179",
pages = "1469--1482.e11",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

AU - Cross-Disorder Group of the Psychiatric Genomics Consortium

AU - Qvist, Per

AU - Dalsgaard, Søren

AU - Christensen, Jane Hvarregaard

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.

AB - Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.

KW - GWAS

KW - Psychiatric genetics

KW - cross-disorder genetics

KW - functional genomics

KW - gene expression

KW - genetic architecture

KW - genetic correlation

KW - neurodevelopment

KW - pleiotropy

KW - psychiatric disorders

UR - http://www.scopus.com/inward/record.url?scp=85076270049&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.11.020

DO - 10.1016/j.cell.2019.11.020

M3 - Journal article

C2 - 31835028

VL - 179

SP - 1469-1482.e11

JO - Cell

JF - Cell

SN - 0092-8674

IS - 7

ER -