TY - JOUR
T1 - Genomic regions associated with ventro-cranial chronic pleuritis in pig
AU - Sørensen, Kirsten Kørup
AU - Gregersen, Vivi Raundahl
AU - Christensen, Ole Fredslund
AU - Velander, Ingela
AU - Bendixen, Christian
PY - 2011
Y1 - 2011
N2 - Ventro-cranial chronic pleuritis can be a result of pleuropneumonia and enzootic pneumonia. These diseases cause severe losses in intensive pig production worldwide, but host resistance is difficult to breed for. It could be beneficial to use marker-assisted selection, and a step towards this is to identify genomic regions associated with the trait. For this purpose, 7304 pigs from 11 boar families were analysed for associations between single nucleotide polymorphisms and ventro-cranial chronic pleuritis. The pigs were genotyped by the use of the iSelect Custom 7 K porcine SNP Chip. Quantitative trait loci (QTL), significant at the chromosome-wide level, were identified on Sus scrofa chromosomes (SSC) 2, 4, 11, 12 and 13 in four different boar families. The QTL on SSC 4 in family G was also significant at the genome-wide threshold according to Bonferroni correction. We have identified a number of candidate genes, but the causative mutations still need to be identified. Markers closely associated with the resistance traits have a strong potential for use in breeding towards animals with improved characteristics concerning ventro-cranial chronic pleuritis
AB - Ventro-cranial chronic pleuritis can be a result of pleuropneumonia and enzootic pneumonia. These diseases cause severe losses in intensive pig production worldwide, but host resistance is difficult to breed for. It could be beneficial to use marker-assisted selection, and a step towards this is to identify genomic regions associated with the trait. For this purpose, 7304 pigs from 11 boar families were analysed for associations between single nucleotide polymorphisms and ventro-cranial chronic pleuritis. The pigs were genotyped by the use of the iSelect Custom 7 K porcine SNP Chip. Quantitative trait loci (QTL), significant at the chromosome-wide level, were identified on Sus scrofa chromosomes (SSC) 2, 4, 11, 12 and 13 in four different boar families. The QTL on SSC 4 in family G was also significant at the genome-wide threshold according to Bonferroni correction. We have identified a number of candidate genes, but the causative mutations still need to be identified. Markers closely associated with the resistance traits have a strong potential for use in breeding towards animals with improved characteristics concerning ventro-cranial chronic pleuritis
KW - Actinobacillus pleuropneumoniae
KW - enzootic pneumonia
KW - lung lesion
KW - Mycoplasma hyopneumoniae
KW - pig breeding
KW - quantitative trait locus
KW - Sus scrofa
U2 - 10.1111/j.1439-0388.2010.00914.x
DO - 10.1111/j.1439-0388.2010.00914.x
M3 - Journal article
C2 - 21749478
SN - 0931-2668
VL - 128
SP - 314
EP - 318
JO - Journal of Animal Breeding and Genetics
JF - Journal of Animal Breeding and Genetics
IS - 4
ER -